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Imaging in cell-based therapy for neurodegenerative diseases

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Fetal cell transplantation for the treatment of Parkinson’s and Huntington’s diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graft’s survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system.

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Abbreviations

AADC:

aromatic l-amino acid decarboxylase

AD:

Alzheimer’s disease

ADC:

apparent diffusion coefficient

BOLD:

blood oxygen level dependent

CIT:

2-β-carbomethoxy-3-β-(4-iodophenyl)tropane

CNTF:

ciliary neurotrophic factor

Cr:

creatine

DA:

dopamine

DAT:

dopamine transporter

DTBZ:

dihydrotetrabenazine

DTI:

diffusion tensor imaging

DWI:

diffusion-weighted imaging

FDG:

fluorodeoxyglucose

GABA:

γ-aminobutyric acid

GAPDH:

glyceraldehyde phosphate dehydrogenase

Gd:

gadolinium

HAP:

Huntington-associated protein

HD:

Huntington’s disease

l-DOPA:

3,4-dihydroxyphenylalanine

MAO:

monoamine oxidase

MRI:

magnetic resonance imaging

MRS:

magnetic resonance spectroscopy

MSA-P:

striatonigral variant of multiple system atrophy

NAA:

N-acetylaspartate

NADPH:

nicotinamide adenine dinucleotide phosphate

NMDA:

N-methyl-d-aspartate

NMR:

nuclear magnetic resonance

NOS:

nitric oxide synthase

PCr:

phosphocreatine

PD:

Parkinson’s disease

PE2I:

N-(3-iodoprop-(2E)-enyl)-2β-carboxymethoxy-3β-(4′-methylphenyl)nortropane

PET:

positron emission tomography

PIB:

Pittsburg Compound-B

SNc:

substantia nigra pars compacta

VTA:

ventral tegmental area

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Acknowledgements

This work was supported by the Swedish Research Council (2003-33SX-14552-01A, 2003-33P-14778-01A, K2005-33IT-15332-1A, K2005-33X-14552-03A), NeuroNE Network of Excellence program of the European Union (LSHM-CT-2004-512039) and the Foundation pour la Recherche Médicale and the Commissariat à l’Energie Atomique. N.B. is a post-doctoral fellow supported by the Marie-Curie training program of the European Union. The authors acknowledge the contribution of V. Gaura, G. Douaud, M.J. Ribeiro, P. Remy, V. Lebon and E.-M. Larsson in the realisation of Fig. 3.

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  1. Section for Neuroscience, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Disease Modeling Group, Lund University, BMC A11, 22184, Lund, Sweden

    Deniz Kirik, Nathalie Breysse & Tomas Björklund

  2. URA CEA CNRS 2210 Isotopic Imaging UIIBP Unit and Program Imagene, Service Hospitalier Frédéric Joliot, 91401, Orsay, France

    Laurent Besret & Philippe Hantraye

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  1. Deniz Kirik
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Correspondence to Deniz Kirik.

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Kirik, D., Breysse, N., Björklund, T. et al. Imaging in cell-based therapy for neurodegenerative diseases. Eur J Nucl Med Mol Imaging 32 (Suppl 2), S417–S434 (2005). https://doi.org/10.1007/s00259-005-1909-6

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