Abstract
The aim of this study was to investigate whether there is a correlation between 99mTc-sestamibi uptake and histological malignancy grade in breast carcinoma. Such a correlation could, prior to surgery and histopathological analysis, facilitate selection of patients who need adjuvant therapy. Ninety-six patients with mammographically determined lesions and/or a palpable tumour suspected for malignancy underwent 99mTc-sestamibi scintimammography prior to surgery. The final diagnosis was determined by histopathological examination. Benign lesions, cancer in situ and tumours located medially in the breast were excluded. Fifty-three invasive cancer lesions in 53 patients were finally included in the study. Planar scintigraphic breast imaging included two prone lateral projections and one anterior supine projection taken 10 min after injection of 700 MBq 99mTc-sestamibi. Focal 99mTc-sestamibi uptake in breast lesions was used as the scintigraphic criterion of abnormality. Tumour to background ratios were calculated with partial volume compensation, and histological malignancy grading was performed according to the Elston classification. A correlation was found between 99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinomas (P≤0.037).
Similar content being viewed by others
References
Taillefer R. The role of99mTc-sestamibi and other conventional radiopharmaceuticals in breast cancer diagnosis. Semin Nucl Med 1999; 29:16–40.
Bonè B, Aspelin P, Bronge L, Veress B. Contrast-enhanced MR imaging as a prognostic indicator of breast cancer. Acta Radiol 1998; 39:279–284.
Donegan W. Staging and primary treatment. In: Donegan W, Spratt J, ed. Cancer of the breast, 4th edn. Philadelphia: Saunders; 1995:392–396.
Tavassoli F. Pathology of the breast. Connecticut: Appelton & Lange; 1992:36.
Boné B, Péntek Z, Perbeck L, Veress B. Diagnostic accuracy of mammography and contrast-enhanced MR imaging in 238 histologically verified breast lesions. Acta Radiol 1997; 8:489–496.
Bonè B, Aspelin P, Bronge L, Isberg B, Perbeck L, Veress B. Sensitivity and specificity of MR mammography with histopathological correlation in 250 breasts. Acta Radiol 1996; 37:208–213.
Villanueva-Mayer J, Leonard MH Jr., Briscone E, et al. Mammoscintigraphy with technetium-99m-sestamibi in suspected breast cancer. J Nucl Med 1996; 37:926–930.
Bombardieri E, Crippa F, Maffioli L, Greco M. Nuclear medicine techniques for the study of breast cancer. Eur J Nucl Med 1997; 24:809–824.
Danielsson R, Boné B, Gad A, Sylvan M, Aspelin P. Sensitivity and specificity of planar scintimammography with 99m-Tc-sestamibi. Acta Radiol 1999; 40:394–399.
Mussurakis S, Buckley D, Horsman A. Dynamic MR imaging of invasive breast cancer: correlation with tumor grade and other histological factors. Br J Radiol 1997; 70:446–451.
Cwikla JB, Buscombe JR, Kolasinska AD, Parbhoo SP, Thakrar DS, Hilson AJ. Correlation between uptake of Tc-99m sestaMIBI and prognostic factors of breast cancer. Anticancer Res 1999; 19:2299–2304.
Elston CW, Ellis IO. Assessment of histologic grade. In: Elston CW, Ellis IO, eds. The breast. Systemic pathology, vol 13. Edinburgh New York: Churchill Livingstone; 1998:366–384.
Sánchez-Crespo A, Jonsson C, Pegerfalk A, Danielsson R, Aspelin P, Larsson S. Quantitative assessment of activity concentrations in small tumours using planar mammoscintigraphy. IFMBE Proceedings of the International Federation of Medical and Biological Engineering. Reykjavik. 2002; 2:88–89.
Contesso G, Mouriesse H, Friedman S, et al. The importance of histologic grade in long term prognosis of breast cancer: a study of 1,010 patients, uniformly treated at the Institut Gustave-Roussy. J Clin Oncol 1987; 5:1378–1386.
Contesso G, Saccani Jotti G, Bonadonna G. Tumor grade as a prognostic factor in primary breast cancer. Eur J Cancer Clin Oncol 1989; 25:403–409.
Robbins S. The female breast. In: Robbins S, ed. Pathologic basis of disease. Philadelphia: Saunders; 1994:1103–1109.
Tabár L, Fagerberg G, Duffy S, et al. Update of the Swedish two-county program of mammographic screening for breast cancer. Radiol Clin North Am 1992; 30:200–204.
Henson D, Ries L, Freedman L, Carragia M. Relationship among outcome, stage of disease, and histological grade for 22,616 cases of breast cancer. Cancer 1991; 68:2142–2149.
Buadu L, Murakami J, Muryama S, et al. Breast lesions: correlation of contrast medium enhancement patterns on MR images with histopathological findings and tumor angiogenesis. Radiology 1996; 200:639–649.
Stomper P, Herman S, Klippenstein D, et al. Analysis of dynamic magnetic resonance imaging enhancement features and cell proliferative activity determined by DNA S-phase percentage. Cancer 1996; 77:1844–1849.
Scorpinaro F, Schillaci O, Scarpini M, et al. Technetium-99m sestamibi: an indicator of breast cancer invasiveness. Eur J Nucl Med 1994; 21:984–987.
Sánchez-Crespo A, Petersson J, Nyren S, Mure M, Glenny Robb W, Thorell J-O, Jacobsson H, Lindahl S, Larsson S. A novel quantitative dual-isotope method for simultaneous ventilation and perfusion lung SPET. Eur J Nucl Med 2002; 29:863–875.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Danielsson, R., Sánchez-Crespo, A., Pegerfalk, A. et al. 99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinoma. Eur J Nucl Med Mol Imaging 30, 662–666 (2003). https://doi.org/10.1007/s00259-003-1132-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00259-003-1132-2