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The importance of MRI review following the diagnosis of atypical cartilaginous tumour using image-guided needle biopsy

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Abstract

Objective

To evaluate the role of pre-biopsy MRI for management planning in patients with atypical cartilaginous tumours (ACT) diagnosed on image-guided core needle biopsy (IGCNB).

Materials and methods

Retrospective review of patients diagnosed with ACT of the appendicular skeleton based on IGCNB who subsequently underwent surgical curettage or resection. Data collected included age, sex, skeletal location and surgical histology classified as ACT, high-grade chondrosarcoma (HG-CS) and dedifferentiated chondrosarcoma (DD-CS). Pre-biopsy MRI studies were reviewed independently by 2 radiologists blinded to surgical histology results and graded as ACT, HG-CS and DD-CS based on MRI features.

Results

The study included 24 males and 28 females (mean age 42.1 years; range 9–76 years). One patient had 2 lesions treated, making a total of 53 lesions. Tumours were located in the femur in 21 cases, humerus in 17, tibia in 9, radius in 4 and ulna and fibula in 1 each. Surgical histology was ACT in 41 cases, HG-CS in 10 and DD-CS in 2, indicating mismatch between IGCNB and surgical histology in 12/53 cases (22.6%). Predicted MRI grade for the 2 readers was ACT in 39 cases each, HG-CS in 13 and 14 cases and DD-CS in 1 and 0 cases. Sensitivity, specificity and accuracy of MRI for predicting HG-CS/DD-CS were 91%, 93% and 92%, respectively. Inter-observer correlation was very good (kappa = 0.94).

Discussion

Review of MRI findings in patients with ACT diagnosed on IGCNB is vital for identifying patients with a HG-CS/DD-CS and is recommended when planning surgical management or considering repeat IGCNB.

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Acknowledgements

The authors would like to acknowledge Mr. Paul Bassett for statistical input.

Author information

Authors and Affiliations

  1. Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK

    Asif Saifuddin, Michael Khoo & Paul O’Donnell

  2. Department of Radiology, London North West Healthcare NHS Trust, London, UK

    Ines Oliveira

  3. Department of Radiology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India

    Nehal Singla

  4. Department of Radiology, West Middlesex University Hospital and Chelsea and Westminster Hospital, London, UK

    Anesh Chavda

  5. Institute of Orthopaedics and Musculoskeletal Science, University College London, London, UK

    Paul O’Donnell

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  1. Asif Saifuddin
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  2. Ines Oliveira
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  4. Anesh Chavda
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Correspondence to Michael Khoo.

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The study was approved by the local Research and Innovation Centre of The Institute of Orthopaedics under the Integrated Research Application System number 262826, with no requirement for informed patient consent.

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Saifuddin, A., Oliveira, I., Singla, N. et al. The importance of MRI review following the diagnosis of atypical cartilaginous tumour using image-guided needle biopsy. Skeletal Radiol 50, 407–415 (2021). https://doi.org/10.1007/s00256-020-03578-7

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  • DOI: https://doi.org/10.1007/s00256-020-03578-7

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