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Pathology of primary malignant bone and cartilage tumours

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Abstract

Bone- and cartilage-forming tumours (osteosarcomas and chondrosarcomas) are rare malignant neoplasms. These tumours are clinically aggressive and often need extensive local and/or systemic treatment. Whereas no other treatment but surgery is currently available for chondrosarcomas, osteosarcomas show an approximately 50–80% response rate to adjuvant chemotherapy. Surgical removal of these tumours is currently mostly performed with limb salvage, but amputation may be required in some cases. In addition, the tumours have a risk of local recurrences adversely affecting the prognosis compared to the primary tumour. In this report we will mainly focus on two of the most prevalent malignant bone tumours, conventional osteosarcoma and conventional chondrosarcoma, and use these to illustrate the problems with the diagnosis of bone sarcomas in general.

Résumé

Les tumeurs malignes d’origine osseuse ou cartilagineuse (ostéosarcomes et chondrosarcomes) sont rares. Elles sont cliniquement agressives et nécessite souvent un traitement extensif, local ou général. Tandis qu’aucun autre traitement que la chirurgie est possible pour le chondrosarcome, l’ostéosarcome a un taux de réponse de 50 à 80% à la chimiothérapie adjuvante. L’ablation chirurgicale de ces tumeurs est le plus souvent menée avec conservation du membre mais une amputation est parfois nécessaire. De plus ces tumeurs ont un risque de récidive, avec un moins bon pronostic que la tumeur initiale. Dans ce rapport, nous considérons essentiellement les deux tumeurs les plus fréquentes—ostéosarcome et chondrosarcome conventionnels—et les utilisons pour illustrer les problèmes de diagnostic des sarcomes osseux en général.

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Authors and Affiliations

  1. Department of Pathology, Leiden University Medical Center, L1-Q, P.O. Box 9600, 2300, RC Leiden, The Netherlands

    L. B. Rozeman, A. M. Cleton-Jansen & P. C. W. Hogendoorn

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  1. L. B. Rozeman
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  2. A. M. Cleton-Jansen
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  3. P. C. W. Hogendoorn
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Correspondence to P. C. W. Hogendoorn.

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Rozeman, L.B., Cleton-Jansen, A.M. & Hogendoorn, P.C.W. Pathology of primary malignant bone and cartilage tumours. International Orthopaedics (SICOT) 30, 437–444 (2006). https://doi.org/10.1007/s00264-006-0212-x

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  • DOI: https://doi.org/10.1007/s00264-006-0212-x

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