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Morphologic imaging in muscular dystrophies and inflammatory myopathies

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Abstract

Objective

To determine if magnetic resonance imaging (MR imaging) is useful in the diagnostic workup of muscular dystrophies and idiopathic inflammatory myopathies for describing the topography of muscle involvement.

Materials and methods

MR imaging was performed in 31 patients: 8 with dystrophic myotony types 1 (n = 4) or 2 (n = 4); 11 with limb-girdle muscular dystrophy, including dysferlinopathy, calpainopathy, sarcoglycanopathy, and dystrophy associated with fukutin-related protein mutation; 3 with Becker muscular dystrophy; and 9 with idiopathic inflammatory myopathies, including polymyositis, dermatomyositis, and sporadic inclusion body myositis.

Results

Analysis of T1 images enabled us to describe the most affected muscles and the muscles usually spared for each muscular disease. In particular, examination of pelvis, thigh, and leg muscles demonstrated significant differences between the muscular diseases. On STIR images, hyperintensities were present in 62% of our patients with muscular dystrophies.

Conclusion

A specific pattern of muscular involvement was established for each muscular disease. Hyperintensities observed on STIR images precede fatty degeneration and are not specific for inflammatory myopathies.

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Authors and Affiliations

  1. Clinique neurologique, CHU de Lille, 59037, Lille Cedex, France

    Adrian Degardin, Arnaud Lacour & Patrick Vermersch

  2. Service de Radiologie Ostéoarticulaire, Hôpital Roger Salengro, CHRU de Lille, Lille Cedex, 59037, France

    David Morillon & Anne Cotten

  3. Institut de Myologie, G-H Pitié-Salpêtrière, 75651, Paris Cedex 13, France

    Tanya Stojkovic

Authors
  1. Adrian Degardin
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  2. David Morillon
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  3. Arnaud Lacour
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  4. Anne Cotten
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  5. Patrick Vermersch
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  6. Tanya Stojkovic
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Correspondence to Adrian Degardin.

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Degardin, A., Morillon, D., Lacour, A. et al. Morphologic imaging in muscular dystrophies and inflammatory myopathies. Skeletal Radiol 39, 1219–1227 (2010). https://doi.org/10.1007/s00256-010-0930-4

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  • DOI: https://doi.org/10.1007/s00256-010-0930-4

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