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Central giant cell granuloma of the jaws: clinical and radiological evaluation of 22 cases

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Abstract

Objective

The objective was to investigate the clinical and radiological characteristics of central giant cell granulomas (CGCGs) of the jaws.

Methods

A retrospective analysis of a 20-year database was performed regarding both clinical and radiological features of 22 patients affected with CGCGs of the jaws.

Results

Fourteen women and 8 men were included with the age range of 7–81 years (mean 31.7 years). Among the 22 lesions, 16 were located in the mandible and 6 in the maxilla. Painless swelling was the most common clinical feature in 18 of all cases. Limited mouth opening was noted in 2 patients where the lesions involved the condyle. Radiographically, 13 lesions were homogeneously osteolytic and 9 lesions were trabeculated. Fifteen lesions were unilocular and 14 lesions presented with well-defined but not sclerotic margins. CT images in 5 patients clearly showed the trabeculation within the lesions. The follow-up ranged from 1.5 to 11 years with a mean period of 5 years. Three out of 9 aggressive and 1 out of 13 nonaggressive lesions developed recurrence.

Conclusions

Diagnosis of CGCGs of the jaws depends on both correct interpretation of clinical, radiographic and pathological data. Differentiation between aggressive and nonaggressive CGCGs should be considered to improve individual treatment planning.

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Acknowledgement

This study was supported by grants from National Natural Science Foundation of China (30600712) to Dr. Z.-J. Sun and (30872894) to Dr. Y.-F. Zhao.

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Authors and Affiliations

  1. Key Laboratory for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan, 430079, Hubei, China

    Zhi-Jun Sun, Yu Cai, Yun-Fei Zheng & Yi-Fang Zhao

  2. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan, 430079, Hubei, China

    Zhi-Jun Sun, Yu Cai & Yi-Fang Zhao

  3. Discipline of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong http://www.hku.hk/

    Roger A. Zwahlen

  4. Department of Oral and Maxillofacial Radiology, School and Hospital of Stomatology, Wuhan University, Wuhan, China

    Shi-Ping Wang

Authors
  1. Zhi-Jun Sun
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  2. Yu Cai
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  3. Roger A. Zwahlen
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  4. Yun-Fei Zheng
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  5. Shi-Ping Wang
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  6. Yi-Fang Zhao
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Corresponding authors

Correspondence to Zhi-Jun Sun or Yi-Fang Zhao.

Additional information

Z.-J. Sun and Y. Cai contributed equally to this work

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Sun, ZJ., Cai, Y., Zwahlen, R.A. et al. Central giant cell granuloma of the jaws: clinical and radiological evaluation of 22 cases. Skeletal Radiol 38, 903–909 (2009). https://doi.org/10.1007/s00256-009-0740-8

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  • DOI: https://doi.org/10.1007/s00256-009-0740-8

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