Abstract
Central giant cell granuloma (CGCG) is an aggressive osteolytic, benign neoplasm of the craniomaxillofacial region. Of all the giant cell lesions, CGCG is the most common and is more prevalent in the Indian population. The etiology and pathogenesis of these lesions still remain an enigma and need to be differentiated from other similar-looking lesions for a proper treatment planning. A case of large destructive CGCG involving the anterior mandibular region, causing extensive bone resorption, and buccal as well as lingual cortical expansion, in a 9-year-old child is presented. It was treated successfully by enucleation and aggressive curettage followed by peripheral ostectomy preserving the continuity of the mandible. Also, a review of the literature has been presented.
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References
Dimitrakopoulos I, Lazaridis N, Sakellariou P, Asimaki A (2006) Giant-cell granuloma in the temporal bone: a case report and review of the literature. J Oral Maxillofac Surg 64:531–536
Garg P, Jain J, De N, Chatterjee K (2017) A central giant cell granuloma in posterior part of maxilla - a case report. Int J Surg Case Rep 30:222–225
Barnes L, Everson J, Reichart P (2005) WHO Classification of Tumours. Pathology and Genetics of Head and Neck Tumours. Lyon: IARC p. 234–5.
Lopez-Arcas JM, Cebrian L, Gonzalez J, Burgueno M (2007) Aneurysmal bone cyst of the mandible: case presentation and review of literature. Med Oral Patol Oral Cir Bucal 12:401–403
Jeyaraj P (2019) Management of central giant cell granulomas of the jaws: an unusual case report with critical appraisal of existing literature. Ann Maxillofac Surg. 9(1):37–47
Abdelkarim AZ, Abu El Sadat SM, Chmieliauskaite M, Syed AZ (2018) Radiographic diagnosis of a central giant cell granuloma using advanced imaging: cone beam computed tomography. Cureus 10(6):2735
Jadu FM, Pharoah MJ, Lee L, Baker GI, Allidina A (2011) Central giant cell granuloma of the mandibular condyle: a case report and review of the literature. Dentomaxillofac Radiol 40(1):60–64
Lange Jande, van den Akker Hans P, van den Berg Henk (2007) Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 104(5):603–615
Ramesh V (2020) Central giant cell granuloma - an update. J Oral Maxillofac Patho 24(3):413–415
Chuong R, Kaban L, Kozakewich H, Perez-Atayde A (1986) Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg 44:708–713
Ficarra G, Kaban L, Hansen L (1987) Central giant cell lesions of the mandible and maxilla: a clinicopathologic and cytometric study. Oral Surg Oral Med Oral Pathol 64:44–49
Wang Y, Le A, El Demellawy D et al (2019) An aggressive central giant cell granuloma in a pediatric patient: case report and review of literature. J Otolaryngol Head Neck Surg 48:32
Kaban LB, Troulis MJ, Ebb D, August M, Hornicek FJ, Dodson TB (2002) Antiangiogenic therapy with interferon alpha for giant cell lesions of the jaws. J Oral Maxillofac Surg 60(10):1103–1111
Pogrel MA (2003) Calcitonin therapy for central giant cell granuloma. J Oral Maxillofac Surg 61(6):649–654
Bayrak NB et al (2018) Treatment of mandibular central giant cell granuloma with administration of systemic calcitonin: A case report. Selcuk Dent J 5:73–79
Tabrizi R, Fardisi S, Zamiri B, Amanpour S, Karagah T (2016) Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granulomaof the jaws? A double-blind clinical trial. Int J Oral Maxillofac Surg 45:756–759
de Lange J, van den Akker HP, van VeldhuijzenZanten GO, Engelshove HA, van den Berg H, Klip H (2006) calcitonin therapy in central giant cell granuloma of the jaw: a randomized double-blind placebo-controlled study. Int J Oral Maxillofac Surg. 35(9):791–5
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Nath, P., Nath, T. Central Giant Cell Granuloma of the Jaw: A Case Report and Review of the Literature. J. Maxillofac. Oral Surg. (2022). https://doi.org/10.1007/s12663-022-01769-4
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DOI: https://doi.org/10.1007/s12663-022-01769-4