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Quantitative assessment of mineralization in distraction osteogenesis

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Abstract

Objectives

The most important decision in distraction osteogenesis is the timing of fixator removal. Various methods have been tried, such as radiographic appearance of callus and bone mineral density (BMD) assessment, but none has acquired gold standard status. The purpose of this study was to develop another objective method of assessment of callus stiffness to help clinicians in taking the most important decision of when to remove the fixator.

Materials and methods

We made a retrospective study of 70 patients to compare the BMD ratio and pixel value ratio. These ratios were calculated at the time of fixator removal, and Pearson’s coefficient of correlation was used to show the comparability. Inter- and intra-observer variability of the new method was also tested.

Results

Good correlation was found between BMD ratio and pixel value ratio, with a Pearson’s coefficient of correlation of 0.79. The interobserver variability was also low, with high intra-observer reproducibility, suggesting that this test was simple to perform.

Conclusion

Pixel value ratio is a good method for assessing callus stiffness, and it can be used to judge the timing of fixator removal.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Korea University, Guro Hospital, Seoul, Korea

    Sunit Hazra, Sandeep Biswal, Ki-Mo Jang & Hitesh N. Modi

  2. Department of Orthopedic Surgery, Rare Diseases Institute, Korea University, Guro Hospital, 80, Guro-Dong, Guro-Gu, Seoul, 152-703, Korea

    Hae-Ryong Song

  3. Department of Orthopedics, Konkuk University Hospital, Seoul, Korea

    Suk-Ha Lee

  4. Department of Orthopedic Surgery, Dongguk University International Hospital, Ilsan, Korea

    Seok Hyun Lee

Authors
  1. Sunit Hazra
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  2. Hae-Ryong Song
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  3. Sandeep Biswal
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  4. Suk-Ha Lee
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  5. Seok Hyun Lee
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  6. Ki-Mo Jang
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  7. Hitesh N. Modi
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Corresponding author

Correspondence to Hae-Ryong Song.

Additional information

The authors certify that they have no commercial associations that might pose a conflict of interest in connection with the submitted article. No benefits in any form have been received or will be received from a commercial party related directly or indirectly to the subject of this article.

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Hazra, S., Song, HR., Biswal, S. et al. Quantitative assessment of mineralization in distraction osteogenesis. Skeletal Radiol 37, 843–847 (2008). https://doi.org/10.1007/s00256-008-0495-7

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  • DOI: https://doi.org/10.1007/s00256-008-0495-7

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