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Peroxy steroids derived from plant and fungi and their biological activities

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Abstract

Peroxides represent a large and interesting group of biologically active natural compounds. All these metabolites contain a peroxide group (R-O-O-R). This review describes studies of more than 60 peroxides isolated from plants and fungi. Most of the plant peroxy steroids exhibit high antiprotozoal (Plasmodium) activity with a confidence of up to 95%, while steroids harvested from fungi show more antineoplastic activity with a confidence of up to 94%. In addition, more than 20 different activities of both groups of peroxides with a probability of 78 to 90% have also been predicted using computer program PASS.

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Acknowledgements

The work was performed in the framework of the Program for Basic Research of Russian State Academies of Sciences for 2013–2020.

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Authors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991

    Vera A. Vil & Alexander O. Terent’ev

  2. Institute of Biomedical Chemistry, Moscow, Russia, 119121

    Tatyana A. Gloriozova & Vladimir V. Poroikov

  3. Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada

    Nick Savidov & Valery M. Dembitsky

  4. Biochemistry Lab, National Scientific Center of Marine Biology, 17 Palchevsky Str, Vladivostok, Russia, 690041

    Valery M. Dembitsky

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  1. Vera A. Vil
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  2. Tatyana A. Gloriozova
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  3. Vladimir V. Poroikov
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  4. Alexander O. Terent’ev
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Vil, V.A., Gloriozova, T.A., Poroikov, V.V. et al. Peroxy steroids derived from plant and fungi and their biological activities. Appl Microbiol Biotechnol 102, 7657–7667 (2018). https://doi.org/10.1007/s00253-018-9211-2

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