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Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss

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Abstract.

Novel immune-type receptor (NITR) genes that encode two extracellular immunoglobulin domains and cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs) have been described previously in three lineages of bony fish. In the current study, four ITIM-containing NITR cDNAs are identified in the rainbow trout (Oncorhynchus mykiss), and their expression patterns and genomic complexity are characterized. The ITIM-containing NITR2 gene maps 1.3 cM from an ITIM-containing C-type lectin receptor (TCL-2) on linkage group XXI. A comprehensive, phylogenetic analysis of NITRs from rainbow trout and three other major lineages of bony fish defines conserved families of NITRs and suggests an ancient lineage of distinct groups of genes. Several probable scenarios that explain the origins of variant forms of NITRs are described.

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Authors and Affiliations

  1. Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA, , , , ,

    Jeffrey A. Yoder

  2. Department of Pediatrics, Children's Research Institute, University of South Florida, 140 Seventh Avenue South, St. Petersburg, FL 33701, USA, , , , ,

    Gary W. Litman

  3. All Children's Hospital, Department of Molecular Genetics, 801 Sixth Street South, St. Petersburg, FL 33701, USA, , , , ,

    Gail M. Mueller

  4. School of Biological Sciences, Washington State University, Pullman, WA 99164, USA, , , , ,

    Krista M. Nichols & Gary H. Thorgaard

  5. Washington State University Agricultural Research Center, 403 Hulbert Hall, Pullman, WA 99164, USA, , , , ,

    Sandra S. Ristow

  6. The Graduate University for Advanced Studies, School of Advanced Sciences, Department of Biosystems Science, Kamiyamaguchi 1560-35, Hayama, Kanagawa, 240-0193, Japan, , , , ,

    Tatsuya Ota

Authors
  1. Jeffrey A. Yoder
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  2. Gail M. Mueller
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  3. Krista M. Nichols
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  4. Sandra S. Ristow
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  5. Gary H. Thorgaard
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  6. Tatsuya Ota
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  7. Gary W. Litman
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Yoder, J.A., Mueller, G.M., Nichols, K.M. et al. Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykiss . Immunogenetics 54, 662–670 (2002). https://doi.org/10.1007/s00251-002-0511-3

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  • DOI: https://doi.org/10.1007/s00251-002-0511-3

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