Abstract
A purified peptide from Androctonus australis Garzoni venom (AaG) affects selectively a K+-current recorded from cerebellum granular cells. This current is characterized by fast activating and inactivating kinetics similar to an IA-type current. Addition of 2 µm peptide Aa1 (from Androctonus australis, toxin 1) to the external side of the channel suppressed completely and in a selective manner the IA-type current, with an IC50 value of 130 nm, whereas in the same conditions, the other potassium current, identified as delayed rectifier (Id), was not affected. Additionally, we show that another partially purified peptide (III-12) from the same venom was able to block reversibly both K+-currents.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 10 February 1997 / Accepted: 7 August 1997
Rights and permissions
About this article
Cite this article
Pisciotta, M., Coronas, F., Possani, L. et al. The Androctonus australis garzoni scorpion venom contains toxins that selectively affect voltage-dependent K+-channels in cerebellum granular cells. Eur Biophys J 27, 69–73 (1998). https://doi.org/10.1007/s002490050112
Issue Date:
DOI: https://doi.org/10.1007/s002490050112