Abstract
“Hair-on-end” skull changes are typically seen in individuals suffering from thalassaemia. They are induced by widening of the diploic space due to marrow expansion that is a consequence of ineffective and excessive erythropoiesis. We present a child with severe congenital neutropenia who exhibited the typical hair-on-end sign on plain skull radiographs and MRI. In this patient the skull changes were very likely induced by the expansion of white blood cell precursors induced by long-term daily injections of recombinant human granulocyte colony stimulating factor (G-CSF) to treat his confounding disease. This case report is the first description of hair-on-end changes associated with the use of G-CSF.
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Albert, M.H., Notheis, G., Wintergerst, U. et al. “Hair-on-end” skull induced by long-term G-CSF treatment in severe congenital neutropenia. Pediatr Radiol 37, 221–224 (2007). https://doi.org/10.1007/s00247-006-0363-3
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DOI: https://doi.org/10.1007/s00247-006-0363-3