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MRI of a family with leukoencephalypathy with vanishing white matter

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Abstract

Leukoencephalopathy with vanishing white matter (VWM) is a newly described entity with characteristic MRI features. We report the cranial MRI findings in three sisters with slowly progressive neurological deterioration. The MRI showed symmetrical diffuse abnormalities of cerebral white matter with hypointensity on FLAIR images. The diagnosis of leukoencephalopathy with VWM was made on the basis of genetic analysis.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, The Children’s Memorial Health Institute, Warsaw, Poland

    Elżbieta Jurkiewicz & Iwona Pakuła-Kościesza

  2. Department of Metabolic Diseases, The Children’s Memorial Health Institute, Warsaw, Poland

    Hanna Mierzewska & Ewa Pronicka

  3. Department of Diagnostic Imaging, Miedzyleski Specialistic Hospital, ul. Bursztynowa 2, 04-749, Warsaw, Poland

    Monika Bekiesińska-Figatowska

  4. Department of Neurology, The Children’s Memorial Health Institute, Warsaw, Poland

    Tomasz Kmieć

  5. Free University Medical Center, Amsterdam, The Netherlands

    Gert Scheper & Marjo S. van der Knaap

Authors
  1. Elżbieta Jurkiewicz
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  2. Hanna Mierzewska
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  3. Monika Bekiesińska-Figatowska
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  4. Iwona Pakuła-Kościesza
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  5. Tomasz Kmieć
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  6. Gert Scheper
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  7. Marjo S. van der Knaap
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  8. Ewa Pronicka
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Corresponding author

Correspondence to Monika Bekiesińska-Figatowska.

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Jurkiewicz, E., Mierzewska, H., Bekiesińska-Figatowska, M. et al. MRI of a family with leukoencephalypathy with vanishing white matter. Pediatr Radiol 35, 1027–1030 (2005). https://doi.org/10.1007/s00247-005-1498-3

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  • DOI: https://doi.org/10.1007/s00247-005-1498-3

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