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Decreased Risk of Strokes in Children with Ventricular Assist Devices Within ACTION

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Abstract

We sought to characterize strokes in children with ventricular assist devices. Of 407 patients in the ACTION registry (4/1/18–5/3/2021), 45 (11%) experienced 52 strokes (45 ischemic and 7 hemorrhagic). Median time to stroke was 23.5 days and 19/52 (37%) occurred ≤ 10 days. Stroke rate was 0.09 and 0.63 strokes per patient-year for implantable continuous and paracorporeal devices, respectively. Patients with stroke were younger, more likely to have congenital heart disease and have been on extracorporeal membrane oxygenation at time of VAD. Based on these data, ACTION is now focused on decreasing strokes in these higher-risk patients with particular attention to the peri-implant period.

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Abbreviations

VAD:

Ventricular assist device

ACTION:

Advanced Cardiac Therapies Improving Outcomes Network

ECMO:

Extracorporeal membrane oxygenation

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Funding

ACTION is funded by research grants from Abbott, Medtronic, Berlin Heart, Syncardia, and Abiomed.

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Authors and Affiliations

  1. University of Michigan Congenital Heart Center, CS Mott Children’s Hospital, Ann Arbor, MI, USA

    David M. Peng

  2. The Heart Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA

    Muhammad F. Shezad, Angela Lorts, Chet R. Villa & Farhan Zafar

  3. Nationwide Children’s Hospital, Columbus, OH, USA

    Robert J. Gajarski

  4. Boston Children’s Hospital, Boston, MA, USA

    Christina VanderPluym & Beth Hawkins

  5. Lucile Packard Children’s Hospital, Stanford University, Palo Alto, CA, USA

    Jenna M. Murray & David N. Rosenthal

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  1. David M. Peng
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  2. Muhammad F. Shezad
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  3. Angela Lorts
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  4. Robert J. Gajarski
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  5. Christina VanderPluym
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  8. Chet R. Villa
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  9. Farhan Zafar
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  10. David N. Rosenthal
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Correspondence to David M. Peng.

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Peng, D.M., Shezad, M.F., Lorts, A. et al. Decreased Risk of Strokes in Children with Ventricular Assist Devices Within ACTION. Pediatr Cardiol 43, 1379–1382 (2022). https://doi.org/10.1007/s00246-022-02863-7

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  • DOI: https://doi.org/10.1007/s00246-022-02863-7

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