Abstract
Patients after the Ross procedure are at risk for right (RV) and left ventricular (LV) dysfunction due to neo-aortic and pulmonary dysfunction. While neo-aortic root dilatation has been related to LV dysfunction, the potential contributions of aortic stiffness and ventricular interactions have not been evaluated. Patients status post Ross procedure up to age 18 years with cardiac magnetic resonance (CMR) exam from 2007 to 2018 were retrospectively reviewed. Aortic pulse wave velocity (PWV) was calculated from phase contrast and angiogram images. RV and LV peak global longitudinal (GLS) and circumferential strain (GCS) were measured using tissue tracking software. Multivariable regression was performed for variables associated with parameters of LV function. In 58 patients (median age 20.5 years at CMR exam), male gender, longer time since Ross procedure, aortic root dilatation, and lower RV ejection fraction (EF) were associated with decreased LV EF. There was no association with LV late gadolinium enhancement or neo-aortic or conduit regurgitation. LV GCS and GLS also correlated with RV GCS, RV GLS and PWV. In multivariable analysis, the relation of RV and LV systolic function, but not aortic measurements, remained significant. In conclusion, in long-term follow-up after pediatric Ross procedure, RV function rather than aortic root size or aortic stiffness most closely relates to LV function. Ventricular interactions may impact decision-making on timing of conduit intervention, which could differ from established criteria in populations with only aortic or pulmonary valve disease. Further study is warranted to evaluate possible association with clinical outcome.
Similar content being viewed by others
References
Ross DN (1967) Replacement of aortic and mitral valves with a pulmonary autograft. Lancet 290(7523):956–958. https://doi.org/10.1016/S0140-6736(67)90794-5
Marino BS, Pasquali SK, Wernovsky G, Pudusseri A, Rychik J, Montenegro L, Shera D, Spray TL, Cohen MS (2008) Accuracy of intraoperative transesophageal echocardiography in the prediction of future neo-aortic valve function after the Ross procedure in children and young adults. Congenit Heart Dis 3(1):39–46. https://doi.org/10.1111/j.1747-0803.2007.00156.x
Kouchoukos NT, Masetti P, Nickerson NJ, Castner CF, Shannon WD, Davila-Roman VG (2004) The Ross procedure: long-term clinical and echocardiographic follow-up. Ann Thorac Surg 78(3):773–781. https://doi.org/10.1016/j.athoracsur.2004.02.033(Discussion 773–781)
Rubay JE, Shango P, Clement S, Ovaert C, Matta A, Vliers A, Sluysmans T (1997) Ross procedure in congenital patients: results and left ventricular function. Eur J Cardiothorac Surg 11(1):92–99
Grotenhuis HB, Westenberg JJ, Doornbos J, Kroft LJ, Schoof PH, Hazekamp MG, Vliegen HW, Ottenkamp J, de Roos A (2006) Aortic root dysfunctioning and its effect on left ventricular function in Ross procedure patients assessed with magnetic resonance imaging. Am Heart J 152(5):e971–e978. https://doi.org/10.1016/j.ahj.2006.06.038
Davlouros PA, Kilner PJ, Hornung TS, Li W, Francis JM, Moon JC, Smith GC, Tat T, Pennell DJ, Gatzoulis MA (2002) Right ventricular function in adults with repaired tetralogy of Fallot assessed with cardiovascular magnetic resonance imaging: detrimental role of right ventricular outflow aneurysms or akinesia and adverse right-to-left ventricular interaction. J Am Coll Cardiol 40(11):2044–2052
Geva T, Sandweiss BM, Gauvreau K, Lock JE, Powell AJ (2004) Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging. J Am Coll Cardiol 43(6):1068–1074. https://doi.org/10.1016/j.jacc.2003.10.045
Burman ED, Keegan J, Kilner PJ (2008) Aortic root measurement by cardiovascular magnetic resonance: specification of planes and lines of measurement and corresponding normal values. Circ Cardiovasc Imaging 1(2):104–113. https://doi.org/10.1161/CIRCIMAGING.108.768911
Brown JW, Ruzmetov M, Vijay P, Rodefeld MD, Turrentine MW (2006) The Ross-Konno procedure in children: outcomes, autograft and allograft function, and reoperations. Ann Thorac Surg 82(4):1301–1306. https://doi.org/10.1016/j.athoracsur.2006.05.001
Ohye RG, Gomez CA, Ohye BJ, Goldberg CS, Bove EL (2001) The Ross/Konno procedure in neonates and infants: intermediate-term survival and autograft function. Ann Thorac Surg 72(3):823–830
Pasquali SK, Cohen MS, Shera D, Wernovsky G, Spray TL, Marino BS (2007) The relationship between neo-aortic root dilation, insufficiency, and reintervention following the Ross procedure in infants, children, and young adults. J Am Coll Cardiol 49(17):1806–1812. https://doi.org/10.1016/j.jacc.2007.01.071
Grotenhuis HB, Westenberg JJ, Steendijk P, van der Geest RJ, Ottenkamp J, Bax JJ, Jukema JW, de Roos A (2009) Validation and reproducibility of aortic pulse wave velocity as assessed with velocity-encoded MRI. J Magn Reson Imaging 30(3):521–526. https://doi.org/10.1002/jmri.21886
Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, Simonsick EM, Havlik R, Lakatta EG, Spurgeon H, Kritchevsky S, Pahor M, Bauer D, Newman A (2005) Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 111(25):3384–3390. https://doi.org/10.1161/circulationaha.104.483628
Cheung EWY, Liang X-c, Lam WWM, Cheung Y-f (2009) Impact of right ventricular dilation on left ventricular myocardial deformation in patients after surgical repair of tetralogy of Fallot. Am J Cardiol 104(9):1264–1270. https://doi.org/10.1016/j.amjcard.2009.06.043
Fernandes FP, Manlhiot C, Roche SL, Grosse-Wortmann L, Slorach C, McCrindle BW, Mertens L, Kantor PF, Friedberg MK (2012) Impaired left ventricular myocardial mechanics and their relation to pulmonary regurgitation, right ventricular enlargement and exercise capacity in asymptomatic children after repair of tetralogy of Fallot. J Am Soc Echocardiogr 25(5):494–503. https://doi.org/10.1016/j.echo.2012.01.014
Wald RM, Haber I, Wald R, Valente AM, Powell AJ, Geva T (2009) Effects of regional dysfunction and late gadolinium enhancement on global right ventricular function and exercise capacity in patients with repaired tetralogy of Fallot. Circulation 119(10):1370–1377. https://doi.org/10.1161/CIRCULATIONAHA.108.816546
Diller GP, Radojevic J, Kempny A, Alonso-Gonzalez R, Emmanouil L, Orwat S, Swan L, Uebing A, Li W, Dimopoulos K, Gatzoulis MA, Baumgartner H (2012) Systemic right ventricular longitudinal strain is reduced in adults with transposition of the great arteries, relates to subpulmonary ventricular function, and predicts adverse clinical outcome. Am Heart J 163(5):859–866. https://doi.org/10.1016/j.ahj.2012.01.038
Bansal N, Kumar SR, Baker CJ, Lemus R, Wells WJ, Starnes VA (2015) Age-related outcomes of the Ross procedure over 20 years. Ann Thorac Surg 99(6):2077–2083. https://doi.org/10.1016/j.athoracsur.2015.02.066(Discussion 2084–2075)
Mookhoek A, Charitos EI, Hazekamp MG, Bogers AJ, Horer J, Lange R, Hetzer R, Sachweh JS, Riso A, Stierle U, Takkenberg JJ, Schoof PH (2015) Ross procedure in neonates and infants: a European multicenter experience. Ann Thorac Surg 100(6):2278–2284. https://doi.org/10.1016/j.athoracsur.2015.08.008
Schneider AW, Putter H, Klautz RJM, Bruggemans EF, Holman ER, Bokenkamp R, Hazekamp MG (2017) Long-term follow-up after the Ross procedure: a single center 22-year experience. Ann Thorac Surg 103(6):1976–1983. https://doi.org/10.1016/j.athoracsur.2016.11.064
Acknowledgements
We would like to thank the University of Michigan Congenital Heart Outcomes Research and Discovery program (MCHORD) for their work and assistance in this study.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflict of interest.
Ethical Approval
This article does not contain any studies with human participants or animals performed by any of the authors. This study was approved by the University of Michigan Institutional Review Board and Human Research Protection Program.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Patel, M.D., Dorfman, A.L., Yu, S. et al. Neo-aortic Root Dilatation, Aortic Stiffness, and Ventricular interactions in Long-Term Follow-Up After the Ross Procedure in Childhood. Pediatr Cardiol 41, 1107–1114 (2020). https://doi.org/10.1007/s00246-020-02360-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00246-020-02360-9