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Physiological Dependency Explains Temperature Differences in Sensitivity Towards Chemical Exposure

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Abstract

In chemical risk assessment, extrapolations from laboratory tests to more realistic conditions are essential to address the toxic effects of pesticides on individuals and populations under field conditions. To transfer toxicological laboratory tests to differing temperature conditions, or outdoor field scenarios, the consideration of temperature dependence is essential and increases realism. Special consideration is given to the impact of temperature on direct sensitivity of organisms to pesticides, for which there are only few modelling approaches available so far. We present a concept for applying physiological temperature dependencies to toxicokinetic–toxicodynamic (TKTD) parameters in the General Uniformed Threshold model of Survival (GUTS). To test this approach in an exemplary study, temperature dependencies from studies on the developmental rate of the mayfly Cloeon dipterum were applied to the parameters of a previously parameterised TKTD model of this species after exposure to imidacloprid. Using a physiologically derived temperature correction for the TKTD rate constants, model predictions for independently conducted toxicology experiments with temperature ranges between 7.8 and 26.4 °C were performed for validation. Our approach demonstrates the successful transfer of a physiological observed temperature dependency on toxicity parameters and survival patterns for Cloeon dipterum and imidacloprid as a case study.

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Acknowledgements

The authors thank Margret Arnold, Timm Knautz and Nils Lippmann for their assistance in the laboratory.

Funding

This work was supported by Bayer AG.

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Authors and Affiliations

  1. Research Institute for Ecosystem Analysis and Assessment (Gaiac), Kackertstrasse 10, 52072, Aachen, Germany

    Kim Rakel, Dino Bussen, Silke Classen & Tido Strauss

  2. Clariant Produkte (Deutschland) GmbH, Am Unisyspark 1, 65843, Sulzbach, Germany

    Dennis Becker

  3. Bayer AG, Alfred-Nobel-Straße 50, 40789, Monheim am Rhein, Germany

    Thomas Preuss & André Gergs

  4. Institute for Ecopreneurship, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Hofackerstrasse 340, 4132, Muttenz, Switzerland

    Armin Zenker

Authors
  1. Kim Rakel
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  2. Dennis Becker
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  4. Silke Classen
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  5. Thomas Preuss
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  6. Tido Strauss
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  7. Armin Zenker
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  8. André Gergs
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Contributions

The study was conceptualised by AG. Experimental studies were planned, conducted and/or supervised by SC, DB, TP and AG. Analytical measurements of imidacloprid for the validation data set 2 (Becker 2011) were performed and provided by AZ. Data analysis and modelling were performed by KR, DB, TS and AG. The first draft of the manuscript was written by KR and TS, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Kim Rakel.

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Competing interests

Financial interests: Authors Kim Rakel, Dino Bussen, Silke Classen and Tido Strauss have received research funding from Bayer AG. Dennis Becker and Armin Zenker declare they have no financial interests. André Gergs and Thomas Preuss are employed at Bayer AG. Imidacloprid is an active ingredient in Bayer products.

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Rakel, K., Becker, D., Bussen, D. et al. Physiological Dependency Explains Temperature Differences in Sensitivity Towards Chemical Exposure. Arch Environ Contam Toxicol 83, 349–360 (2022). https://doi.org/10.1007/s00244-022-00963-2

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