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Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT

  • DIAGNOSTIC NEURORADIOLOGY
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Abstract

We report cerebral SPECT studies on two siblings with the syndrome of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Tc-99m HMPAO brain SPECT was performed 8, 19 and 30 days after a stroke-like episode in one case and 10 days after a stroke-like episode, 6 h after a partial seizure and as a follow-up study in the other. Increased blood flow was seen in both these patients with stroke-like episodes due to MELAS. The cause of the increased blood flow is uncertain, but it may be related to the decreased pH created by local increase in lactic acid.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Taipei Veterans General Hospital, National Yang-Ming University, 201 Sec. 2, Shih-Pai Road, Taipei, Taiwan, 11217, Republic of China e-mail: rsliu@npcc.gov.tw, Tel.: + 88 62-8 75-71 31, Fax: + 88 62-8 74-94 31, , , , , , TW

    R. S. Liu

  2. Department of Nuclear Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, , , , , , TW

    N. J. Peng & D. G. Tsay

  3. Division of Neurology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, , , , , , TW

    J. Y. Li & K. W. Kong

  4. Division of Nuclear Medicine, Department of Radiology, Stanford University Medical Center, California, USA, , , , , , US

    C. G. Kwok & H. W. Strauss

Authors
  1. N. J. Peng
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  2. R. S. Liu
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  3. J. Y. Li
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  4. D. G. Tsay
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  5. K. W. Kong
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  6. C. G. Kwok
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  7. H. W. Strauss
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Additional information

Received: 30 December 1997/Accepted: 18 March 1999

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Peng, N., Liu, R., Li, J. et al. Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT. Neuroradiology 42, 26–29 (2000). https://doi.org/10.1007/s002340050005

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  • DOI: https://doi.org/10.1007/s002340050005

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