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The effects of cidofovir on progressive multifocal leukoencephalopathy: an MRI case study

  • DIAGNOSTIC NEURORADIOLOGY
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Abstract

MRI was used to study the effects of introducing cidofovir (HPMPC, Vistide) to the antiretroviral therapy of a 33-year-old white man diagnosed as having progressive multifocal leukoencephalopathy (PML) secondary to AIDS. In response to combined cidofovir and antiretroviral therapy he showed significant clinical improvement. MRI showed a decrease in extent of existing lesions, without new ones. Blood chemistry information obtained indicated some involvement of immunologic mechanisms: the CD4:8 ratio showed improvement from an average of 0.08 before treatment to 0.13 during therapy.

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Authors and Affiliations

  1. Physics Department, Texas Technical University, Lubbock, TX 79409, USA e-mail: vckrc@ttu.edu Tel.: + 1-8 06-7 42 37 67 Fax: + 1-8 06-7 42 11 82, , , , , , US

    R. L. Cardenas & K. H. Cheng

  2. Mount Diablo Medical Center, Concord, CA 94520, USA, , , , , , US

    K. Sack

Authors
  1. R. L. Cardenas
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  2. K. H. Cheng
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  3. K. Sack
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Received: 24 January 2000 Accepted: 6 September 2000

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Cardenas, R., Cheng, K. & Sack, K. The effects of cidofovir on progressive multifocal leukoencephalopathy: an MRI case study. Neuroradiology 43, 379–382 (2001). https://doi.org/10.1007/s002340000495

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  • DOI: https://doi.org/10.1007/s002340000495

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