Abstract
Progressive multifocal leukoencephalopathy (PML) is a severe demyelinating disease of the central nervous system caused by reactivation of the polyomavirus JC (JCV). Human immunodeficiency virus (HIV) infection is one of the leading causes of PML which has high morbidity and mortality due to the lack of a proven standard treatment. We found clinical and radiological improvement with the combination of high-dose methylprednisolone, mirtazapine, mefloquine, and IVIG in our patient who presented with neurological symptoms and had diagnosed concurrent acquired immunodeficiency syndrome (AIDS) and PML. To our knowledge, our case is the first HIV-associated PML which responded to this combination therapy.
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All authors contributed to study conception and design. BC and YY collected the data. BC, YY, EA, and HH wrote the first manuscript draft. All authors were involved in the care of the patient. All authors participated in the interpretation of the data. All authors read and approved the final manuscript.
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Cifci, B., Yildiz, Y., Altin, E. et al. Successful treatment of HIV-associated progressive multifocal leukoencephalopathy (PML) with mirtazapine, mefloquine, and IVIG combination therapy: a case report. J. Neurovirol. 29, 111–115 (2023). https://doi.org/10.1007/s13365-023-01114-6
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DOI: https://doi.org/10.1007/s13365-023-01114-6