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Altered functional connectivity within and between resting-state networks in patients with vestibular migraine

  • Functional Neuroradiology
  • Published:
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Abstract

Purpose

Previous functional magnetic resonance imaging studies have substantiated changes in multiple brain regions of functional activity in patients with vestibular migraine. However, few studies have assessed functional connectivity within and between specific brain networks in vestibular migraine.

Methods

Our study subjects included 37 patients with vestibular migraine and 35 healthy controls, and the quality of magnetic resonance images of all subjects met the requirements. Independent component analysis was performed to identify resting-state networks, and we investigated changes in functional connectivity patterns within and between brain networks. We also used Pearson correlation analysis to assess the relationship between changes in functional connectivity and the clinical features of patients with vestibular migraine.

Results

A total of 14 independent components were identified. Compared to healthy controls, patients with vestibular migraine exhibited decreased intra-network functional connectivity in the executive control network and weakened functional connectivity between the anterior default mode network and the ventral attention network, between the anterior default mode network and the salience network, and between the right frontoparietal network and the auditory network. Moreover, the functional connectivity between the salience network and the dorsal attention network was increased. However, the functional connectivity of networks and clinical characteristics of vestibular migraine patients did not demonstrate any significant correlation.

Conclusion

In conclusion, our study suggested that patients with vestibular migraine also have abnormal multisensory integration during the interictal period and that the attention network is involved. Changing within- and between-network functional connectivity may indicate that vestibular cortex areas are in a sensitive state.

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Author notes

  1. Lin Han and Jiajie Lu contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, China

    Lin Han, Jiajie Lu & Hongru Zhao

  2. Department of Neurology, Sir Run Run Hospital of Nanjing Medical University, Nanjing, China

    Can Chen

  3. Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, China

    Jun Ke

Authors
  1. Lin Han
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  2. Jiajie Lu
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  3. Can Chen
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  4. Jun Ke
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  5. Hongru Zhao
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Correspondence to Hongru Zhao.

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The study protocol was in accordance with the Declaration of Helsinki and was approved by the ethics committee of the First Affiliated Hospital of Soochow University.

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Han, L., Lu, J., Chen, C. et al. Altered functional connectivity within and between resting-state networks in patients with vestibular migraine. Neuroradiology 65, 591–598 (2023). https://doi.org/10.1007/s00234-022-03102-9

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  • DOI: https://doi.org/10.1007/s00234-022-03102-9

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