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Contralesional macrostructural plasticity in patients with frontal low-grade glioma: a voxel-based morphometry study

  • Functional Neuroradiology
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Abstract

Purpose

Neuroplasticity can partially compensate for the neurological deficits caused by brain tumors. However, the structural plasticity of the brain caused by brain tumors is not fully understood. This study aimed to assess the structural plasticity of the contralesional hemisphere in patients with frontal low-grade gliomas (LGGs).

Methods

A total of 25 patients with left frontal LGGs (LFLGGs), 19 patients with right frontal LGGs (RFLGGs), and 25 healthy controls (HCs) were enrolled in this study. High-resolution structural T1-weighted imaging and fluid attenuation inversion recovery were performed on all participants. Voxel-based morphometry (VBM) analysis was used to detect differences in the brain structural plasticity between patients with unilateral LGGs and HCs.

Results

VBM analysis revealed that compared with HCs, the gray matter volume (GMV) of the contralesional putamen and amygdala was significantly smaller and larger in the patients with RFLGGs and LFLGGs, respectively, while the GMVs of the contralesional cuneus and superior temporal gyrus (STG) were significantly larger in the patients with LFLGGs. The surviving clusters of the right hemisphere included 1357 voxels in the amygdala, 1680 voxels in the cuneus, 384 voxels in the STG, and 410 voxels in the putamen. The surviving clusters of the left hemisphere were 522 voxels in the amygdala and 320 voxels in the putamen.

Conclusion

The unilateral frontal LGGs are accompanied by structural plasticity in the contralesional cortex and vary with tumor laterality. Contralesional structural reorganization may be one of the physiological basis for functional reorganization or compensation in the frontal LGGs.

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Acknowledgements

None.

Funding

This work was supported by the Clinical Research Plan of SHDC, no. SHDC2020CR3020A; Research Startup Fund of Huashan Hospital Fudan University, no. 2021QD035; Shanghai Sailing Program, no. 22YF1405000; Shanghai Municipal Commission of Science and Technology, no. 22S31905300; Greater Bay Area Institute of Precision Medicine (Guangzhou), no. KCH2310094.

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Author notes

  1. Kun Lv and Xin Cao contributed equally to this work.

Authors and Affiliations

  1. Department of Radiology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China

    Kun Lv, Xin Cao, Rong Wang, Qingqing Lu, Jun Zhang & Daoying Geng

  2. Department of Radiology, Ningbo First Hospital, Ningbo, China

    Qingqing Lu

  3. Department of Neurology, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China

    Jianhong Wang

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  1. Kun Lv
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  2. Xin Cao
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Contributions

All the authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Kun Lv, Xin Cao, Rong Wang, and Qingqing Lu. The first draft of the manuscript was written by Kun Lv, and all the authors commented on previous versions of the manuscript. All the authors read and approved the final manuscript.

Corresponding authors

Correspondence to Jianhong Wang, Jun Zhang or Daoying Geng.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Lv, K., Cao, X., Wang, R. et al. Contralesional macrostructural plasticity in patients with frontal low-grade glioma: a voxel-based morphometry study. Neuroradiology 65, 297–305 (2023). https://doi.org/10.1007/s00234-022-03059-9

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  • DOI: https://doi.org/10.1007/s00234-022-03059-9

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