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Arterial spin labeling of hemangioblastoma: differentiation from metastatic brain tumors based on quantitative blood flow measurement

  • Diagnostic Neuroradiology
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Abstract

Introduction

Hemangioblastoma and metastatic tumors are the major differential diagnoses for the posterior fossa tumors in adults. Our purpose was to evaluate the efficacy of ASL in differentiating hemangioblastomas from metastatic brain tumors.

Methods

A total of 19 patients including 5 with a hemangioblastomas and 14 with metastatic tumors (7 from lung cancer, 4 from breast cancer, 1 from RCC, 1 from gastric cancer, and 1 from unknown origin) were enrolled in this study. ASL was performed using a pulsed ASL method at a 3-T unit. aTBF was measured as a mean absolute blood flow value within a region of interest drawn in the tumor. In addition, rTBF was obtained by normalizing the aTBF by a blood flow measured in the normal-appearing cortical gray matter. The aTBF and rTBF values were compared between hemangioblastomas and metastatic tumors using Student’s t test.

Results

Both the aTBF and rTBF values were significantly higher in hemangioblastomas (mean aTBF ± SD = 437 ± 274 mL/100 g/min, mean rTBF ± SD = 7.96 ± 3.12) in comparison with metastatic brain tumors (mean aTBF ± SD = 125 ± 134 mL/100 g/min, mean rTBF ± SD = 2.98 ± 3.91; p < 0.05, respectively). However, a metastasis from RCC showed very high aTBF (559 mL/100 g/min) and rTBF (16.2).

Conclusion

Our results demonstrated that ASL provides useful information to differentiate between hemangioblastomas and metastatic brain tumors. Metastasis from RCC may mimic hemangioblastoma on ASL blood flow measurement.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Koji Yamashita, Takashi Yoshiura, Akio Hiwatashi, Osamu Togao, Kazufumi Kikuchi & Hiroshi Honda

  2. Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Koji Yoshimoto & Masahiro Mizoguchi

  3. Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Satoshi O. Suzuki & Toru Iwaki

Authors
  1. Koji Yamashita
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  2. Takashi Yoshiura
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  3. Akio Hiwatashi
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  4. Osamu Togao
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  5. Koji Yoshimoto
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  6. Satoshi O. Suzuki
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  7. Kazufumi Kikuchi
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  8. Masahiro Mizoguchi
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  9. Toru Iwaki
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  10. Hiroshi Honda
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Corresponding author

Correspondence to Takashi Yoshiura.

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Yamashita, K., Yoshiura, T., Hiwatashi, A. et al. Arterial spin labeling of hemangioblastoma: differentiation from metastatic brain tumors based on quantitative blood flow measurement. Neuroradiology 54, 809–813 (2012). https://doi.org/10.1007/s00234-011-0977-5

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  • DOI: https://doi.org/10.1007/s00234-011-0977-5

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