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Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus

Neuroradiology volume 54, pages 189–196 (2012)Cite this article

Abstract

Introduction

Normal pressure hydrocephalus (NPH) represents a chronic neurological disorder with increasing incidence. The symptoms of NPH may be relieved by surgically implanting a ventriculoperitoneal shunt to drain excess cerebrospinal fluid. However, the pathogenesis of NPH is not yet fully elucidated, and the clinical response of shunt treatment is hard to predict. According to current theories of NPH, altered mechanical properties of brain tissue seem to play an important role. Magnetic resonance elastography (MRE) is a unique method for measuring in vivo brain mechanics.

Methods

In this study cerebral MRE was applied to test the viscoelastic properties of the brain in 20 patients with primary (N = 14) and secondary (N = 6) NPH prior and after (91 ± 16 days) shunt placement. Viscoelastic parameters were derived from the complex modulus according to the rheological springpot model. This model provided two independent parameters μ and α, related to the inherent rigidity and topology of the mechanical network of brain tissue.

Results

The viscoelastic parameters μ and α were found to be decreased with −25% and −10%, respectively, compared to age-matched controls (P < 0.001). Interestingly, α increased after shunt placement (P < 0.001) to almost normal values whereas μ remained symptomatically low.

Conclusion

The results indicate the fundamental role of altered viscoelastic properties of brain tissue during disease progression and tissue repair in NPH. Clinical improvement in NPH is associated with an increasing complexity of the mechanical network whose inherent strength, however, remains degraded.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Neurosurgical Department, Charité—University Medicine Berlin, Campus Virchow-Klinikum, 13353, Berlin, Germany

    Florian Baptist Freimann & Christian Sprung

  2. Department of Radiology, Charité—University Medicine Berlin, Campus Charité Mitte, Charitéplatz 1, 10117, Berlin, Germany

    Kaspar-Josche Streitberger, Dieter Klatt & Ingolf Sack

  3. Mathematics Department, Rensselaer Polytechnic Institute, Troy, NY, USA

    Kui Lin & Joyce McLaughlin

  4. Institute of Medical Informatics, Charité—University Medicine Campus Benjamin Franklin, 12200, Berlin, Germany

    Jürgen Braun

Authors
  1. Florian Baptist Freimann
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  2. Kaspar-Josche Streitberger
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  3. Dieter Klatt
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  4. Kui Lin
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  5. Joyce McLaughlin
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  6. Jürgen Braun
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  7. Christian Sprung
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  8. Ingolf Sack
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Corresponding authors

Correspondence to Christian Sprung or Ingolf Sack.

Additional information

Florian Baptist Freimann and Kaspar-Josche Streitberger have contributed equally to this work.

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Freimann, F.B., Streitberger, KJ., Klatt, D. et al. Alteration of brain viscoelasticity after shunt treatment in normal pressure hydrocephalus. Neuroradiology 54, 189–196 (2012). https://doi.org/10.1007/s00234-011-0871-1

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  • DOI: https://doi.org/10.1007/s00234-011-0871-1

Keywords

  • Normal pressure hydrocephalus
  • Shunt
  • Magnetic resonance elastography (MRE)
  • Viscoelasticity
  • Springpot