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Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Introduction

We attempted to detect alterations in the cerebrospinal fluid (CSF) space in patients with idiopathic normal pressure hydrocephalus (iNPH) using voxel-based morphometry (VBM).

Methods

We obtained sagittal volume images of the entire head by three-dimensional T1-weighted magnetic resonance imaging and compared the regional distribution of CSF in 12 patients with iNPH, 14 patients with Alzheimer’s disease (AD), and 17 healthy individuals using VBM with automatically extracted CSF objects.

Results

VBM demonstrated significant widening at the lateral ventricles and Sylvian fissures and narrowing of the CSF space at the high convexity/midline areas in iNPH patients, compared to the AD patients and healthy controls (p < 0.05, after correction with a false-discovery rate). In addition, the ratio of the CSF volume in the lateral ventricle/Sylvian fissure area to that in the high convexity/midline area in iNPH patients (3.9 ± 1.2) was remarkably greater than that in AD patients (1.2 ± 0.3) and controls (0.9 ± 0.3; one-way ANOVA, p < 0.001; post hoc Tukey’s test, p < 0.001); we could discriminate iNPH patients from those in the other two groups without any overlap, when using a cutoff level of 1.9.

Conclusion

VBM using CSF objects can be used to delineate the characteristic alteration of the CSF space in iNPH patients, which has been evaluated by visual interpretation.

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Acknowledgments

This work was partially supported by a Health and Labour Sciences Research Grant from the Ministry of Health, Labor, and Welfare, Japan (2008-Nanchi-17) and by a Grant-in-Aid for Strategic Medical Science Research Center from the Ministry of Education, Culture, Sports, Science, and Technology, Japan.

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Clinical Neuroscience, Medical Sciences for Control of Pathological Process, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tenno-dai, Tsukuba-shi, Ibaraki-ken, 305-8577, Japan

    Fumio Yamashita & Takashi Asada

  2. Advanced Medical Research Center, Iwate Medical University, Morioka, Japan

    Makoto Sasaki & Kohsuke Kudo

  3. Department of Neurology, Iwate Medical University, Morioka, Japan

    Satoshi Takahashi, Shinsuke Narumi & Yasuo Terayama

  4. Department of Nuclear Medicine, Saitama Medical University International Medical Center, Saitama, Japan

    Hiroshi Matsuda

Authors
  1. Fumio Yamashita
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  2. Makoto Sasaki
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  3. Satoshi Takahashi
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  4. Hiroshi Matsuda
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  5. Kohsuke Kudo
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  6. Shinsuke Narumi
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  7. Yasuo Terayama
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  8. Takashi Asada
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Corresponding author

Correspondence to Fumio Yamashita.

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Yamashita, F., Sasaki, M., Takahashi, S. et al. Detection of changes in cerebrospinal fluid space in idiopathic normal pressure hydrocephalus using voxel-based morphometry. Neuroradiology 52, 381–386 (2010). https://doi.org/10.1007/s00234-009-0610-z

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  • DOI: https://doi.org/10.1007/s00234-009-0610-z

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