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Apparent diffusion coefficient vale of the brain in patients with Gaucher’s disease type II and type III

  • Paediatric Neuroradiology
  • Published:
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Abstract

Introduction

The aim of this work is to assess the usefulness of apparent diffusion coefficient (ADC) value of the brain for diagnosis of patients with Gaucher’s disease type II and type III.

Methods

Prospective study was conducted upon 13 patients (nine boys and four girls aged 8 months–14 years: mean 6.1 years) with Gaucher’s disease type II and III and for age-matched control group (n = 13). Diffusion-weighted magnetic resonance imaging using a single-shot echo-planar imaging with a diffusion-weighted factor b of 0, 500, and 1,000 s/mm2 was done for all patients and volunteers. The ADC value was calculated in ten regions of the brain parenchyma and correlated with genotyping.

Results

There was significantly lower ADC value of the cortical frontal (P = 0.003), cortical temporal (P = 0.04), frontal subcortical white matter (P = 0.02), corticospinal tract (P = 0.001), cerebellum (P = 0.001), medulla (P = 0.002), and midbrain (P = 0.02) between patients and volunteers. There was significant difference in the ADC value of the frontal and temporal gray matter (P = 0.04 and 0.05, respectively) between patients with heterozygous and homozygous gene mutation.

Conclusion

We concluded that ADC value is a new promising quantitative imaging parameter that can be used for the detection of brain abnormalities in patients with Gaucher’s disease type II and type III and has a correlation with genotyping.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, Mansoura Faculty of Medicine, Mansoura, Egypt

    Ahmed Abdel Khalek Abdel Razek & Nahed Abd El-Gaber

  2. Department of Pediatric, Mansoura Faculty of Medicine, Mansoura, Egypt

    Ahmed Abdalla & Abeer Fathy

  3. Department of Neurology, Mansoura Faculty of Medicine, Mansoura, Egypt

    Ahmed Azab

  4. Radiology Unit of Pediatric Hospital, Mansoura, Egypt

    Ashraf Abdel Rahman

Authors
  1. Ahmed Abdel Khalek Abdel Razek
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  2. Nahed Abd El-Gaber
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  3. Ahmed Abdalla
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  4. Abeer Fathy
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  5. Ahmed Azab
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Correspondence to Ahmed Abdel Khalek Abdel Razek.

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Abdel Razek, A.A.K., Abd El-Gaber, N., Abdalla, A. et al. Apparent diffusion coefficient vale of the brain in patients with Gaucher’s disease type II and type III. Neuroradiology 51, 773–779 (2009). https://doi.org/10.1007/s00234-009-0548-1

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  • DOI: https://doi.org/10.1007/s00234-009-0548-1

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