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Statistical parametric mapping and statistical probabilistic anatomical mapping analyses of basal/acetazolamide Tc-99m ECD brain SPECT for efficacy assessment of endovascular stent placement for middle cerebral artery stenosis

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Introduction

Statistical parametric mapping (SPM) and statistical probabilistic anatomical mapping (SPAM) were applied to basal/acetazolamide Tc-99m ECD brain perfusion SPECT images in patients with middle cerebral artery (MCA) stenosis to assess the efficacy of endovascular stenting of the MCA.

Methods

Enrolled in the study were 11 patients (8 men and 3 women, mean age 54.2 ± 6.2 years) who had undergone endovascular stent placement for MCA stenosis. Using SPM and SPAM analyses, we compared the number of significant voxels and cerebral counts in basal and acetazolamide SPECT images before and after stenting, and assessed the perfusion changes and cerebral vascular reserve index (CVRI).

Results

The numbers of hypoperfusion voxels in SPECT images were decreased from 10,083 ± 8,326 to 4,531 ± 5,091 in basal images (P = 0.0317) and from 13,398 ± 14,222 to 7,699 ± 10,199 in acetazolamide images (P = 0.0142) after MCA stenting. On SPAM analysis, the increases in cerebral counts were significant in acetazolamide images (90.9 ± 2.2 to 93.5 ± 2.3, P = 0.0098) but not in basal images (91 ± 2.7 to 92 ± 2.6, P = 0.1602). The CVRI also showed a statistically significant increase from before stenting (median 0.32; 95% CI −2.19–2.37) to after stenting (median 1.59; 95% CI −0.85–4.16; P = 0.0068).

Conclusion

This study revealed the usefulness of voxel-based analysis of basal/acetazolamide brain perfusion SPECT after MCA stent placement. This study showed that SPM and SPAM analyses of basal/acetazolamide Tc-99m brain SPECT could be used to evaluate the short-term hemodynamic efficacy of successful MCA stent placement.

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Acknowledgement

This study was supported by a grant from the Korea Ministry of Science and Technology Radiation Applied Neuroscience (M2 050407000405A070700410).

Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, College of Medicine, Pusan National University Hospital, Busan, Republic of Korea

    Tae-Hong Lee

  2. Medical Research Institute, Pusan National University Hospital, Busan, Republic of Korea

    Tae-Hong Lee, Seong-Jang Kim, In-Ju Kim, Yong-Ki Kim, Dong-Soo Kim & Kyung-Pil Park

  3. Department of Nuclear Medicine and Medical Research Institute, Pusan National University Hospital, 1-10, Ami-dong, Seo-gu, 602-739, Busan, Republic of Korea

    Seong-Jang Kim, In-Ju Kim & Yong-Ki Kim

  4. Department of Neurology, College of Medicine, Pusan National University Hospital, Busan, Republic of Korea

    Kyung-Pil Park

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  1. Tae-Hong Lee
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Correspondence to Seong-Jang Kim.

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Lee, TH., Kim, SJ., Kim, IJ. et al. Statistical parametric mapping and statistical probabilistic anatomical mapping analyses of basal/acetazolamide Tc-99m ECD brain SPECT for efficacy assessment of endovascular stent placement for middle cerebral artery stenosis. Neuroradiology 49, 289–298 (2007). https://doi.org/10.1007/s00234-006-0188-7

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  • DOI: https://doi.org/10.1007/s00234-006-0188-7

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