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Dysfunction of Rice Mitochondrial Membrane Induced by Yb3+

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Abstract

Ytterbium (Yb), a widely used rare earth element, is treated as highly toxic to human being and adverseness to plant. Mitochondria play a significant role in plant growth and development, and are proposed as a potential target for ytterbium toxicity. In this paper, the biological effect of Yb3+ on isolated rice mitochondria was investigated. We found that Yb3+ with high concentrations (200 ~ 600 μM) not only induced mitochondrial membrane permeability transition (mtMPT), but also disturbed the mitochondrial ultrastructure. Moreover, Yb3+ caused the respiratory chain damage, ROS formation, membrane potential decrease, and mitochondrial complex II activity reverse. The results above suggested that Yb3+ with high concentrations could induce mitochondrial membrane dysfunction. These findings will support some valuable information to the safe application of Yb-based agents.

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Acknowledgments

We gratefully acknowledge the financial support from the National Natural Science Foundation of China (Grant Nos. 21173026, 21225313) and Wuhan Yellow Crane Talents Plan of Science and Technology (2014).

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Authors and Affiliations

  1. Department of Chemistry, College of Chemistry and Environmental Engineering, Yangtze University, Jingzhou, 434023, Hubei, People’s Republic of China

    Jia-Ling Gao, Man Wu, Wen Liu, Zhi-Jiang Feng, Ye-Zhong Zhang, Yi Liu & Jie Dai

  2. State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (MOE), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People’s Republic of China

    Feng-Lei Jiang & Yi Liu

Authors
  1. Jia-Ling Gao
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  2. Man Wu
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  3. Wen Liu
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  4. Zhi-Jiang Feng
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  5. Ye-Zhong Zhang
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  6. Feng-Lei Jiang
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  7. Yi Liu
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  8. Jie Dai
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Correspondence to Jie Dai.

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Gao, JL., Wu, M., Liu, W. et al. Dysfunction of Rice Mitochondrial Membrane Induced by Yb3+ . J Membrane Biol 248, 1159–1165 (2015). https://doi.org/10.1007/s00232-015-9833-6

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  • DOI: https://doi.org/10.1007/s00232-015-9833-6

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