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Exploiting the Role of Resveratrol in Rat Mitochondrial Permeability Transition

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Abstract

Resveratrol (RSV), a natural polyphenolic antioxidant, has been considered an anticarcinogenic agent as it triggers tumor cell apoptosis through activation of the mitochondrial pathway. In our study, the effects of RSV on mitochondria, especially on the mitochondrial permeability transition (MPT) process, were investigated by multiple methods. We found that RSV induced a collapse of membrane potential and matrix swelling related to MPT. We further demonstrated that Ca2+ was necessary for this RSV-induced MPT opening. In addition, RSV induced the inner membrane permeabilization to H+ and K+, the depression of respiration and changes in membrane fluidity. The results suggested that RSV-induced MPT was accompanied by mitochondrial dysfunction. But the prohibition on lipid peroxidation and different effects of low- and high-dose RSV on membrane fluidity and respiration showed that the interaction of RSV and the mitochondria could not be the result of a single simple mechanism.

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Acknowledgments

The authors gratefully acknowledge financial support from the National Natural Science Foundation of China (Grants 21077081, 21273065, 21203035, 20921062) and the National Science Foundation for Distinguished Young Scholars of China (Grant 21225313).

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Authors and Affiliations

  1. State Key Laboratory of Virology & Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, People’s Republic of China

    Yue Zhang, Fangfang Tian, Qi Xiao, Jiahan Li, Fenglei Jiang & Yi Liu

  2. Hubei Key Laboratory of Pollutant Analysis & Reuse Technology, Department of Chemistry, Hubei Normal University, Huangshi, 435002, People’s Republic of China

    Yanjun Hu

  3. College of Chemistry and Life Sciences, Guangxi Teachers Education University, Nanning, 530001, People’s Republic of China

    Qi Xiao

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  1. Yue Zhang
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Correspondence to Yi Liu.

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Zhang, Y., Tian, F., Xiao, Q. et al. Exploiting the Role of Resveratrol in Rat Mitochondrial Permeability Transition. J Membrane Biol 246, 365–373 (2013). https://doi.org/10.1007/s00232-013-9540-0

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  • DOI: https://doi.org/10.1007/s00232-013-9540-0

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