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AQPs and Control of Vesicle Volume in Secretory Cells

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Abstract

Aquaporins (AQPs) are a family of small, hydrophobic, integral membrane proteins. In mammals, they are expressed in many epithelia and endothelia and function as channels that permit water or small solutes to pass. Although the AQPs reside constitutively at the plasma membrane in most cell types, the presence of AQPs in intracellular organelles such as secretory granules and vesicles has currently been demonstrated. The secretory granules and vesicles contain secretory proteins, migrate to particular locations within the cell close to the plasma membrane and release their contents to the outside. During the process, including exocytosis, regulation of secretory granule or vesicle volume is important. This paper reviews the possible role of AQPs in secretory granules and vesicles.

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Acknowledgements

This study was supported in part by a Grant-in-Aid for Scientific Research from JSPS (16390534)

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Authors and Affiliations

  1. Department of Physiology and Research Institute of Oral Science, Nihon University School of Dentistry at Matsudo, Matsudo, Chiba, 271-8587, Japan

    H. Sugiya

  2. Oral Health Science Center and Department of Pathology, Tokyo Dental College, Mihama, Chiba, 261-8502, Japan

    M. Matsuki

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  1. H. Sugiya
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  2. M. Matsuki
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Correspondence to H. Sugiya.

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Sugiya, H., Matsuki, M. AQPs and Control of Vesicle Volume in Secretory Cells. J Membrane Biol 210, 155–159 (2006). https://doi.org/10.1007/s00232-005-0853-5

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  • DOI: https://doi.org/10.1007/s00232-005-0853-5

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