Abstract.
Laminin, the major basement membrane glycoprotein of the blood vessel, inducing many cellular responses, inhibited the differentiation of osteoclasts in a rat bone marrow culture system when immobilized on the surface of the culture wells, showing that laminin acts as a negative regulator of osteoclast differentiation in a nonsolubilized form. Laminin inhibited the process of preosteoclast formation from early progenitor cells in bone marrow. This laminin-mediated inhibition of osteoclastogenesis was blocked by the addition of laminin fragment YIGSR, indicating that the inhibitory effect of laminin was mediated via laminin receptors. This finding suggests a significant role of basement membrane laminin of the blood vessels as a negative regulator of osteoclastogenesis.
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Received: 30 September 1996 / Accepted: 20 February 1998
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Kukita, T., Hata, K., Kukita, A. et al. Laminin, a Major Basement Membrane Component of the Blood Vessel, as a Negative Regulator of Osteoclastogenesis. Calcif Tissue Int 63, 140–142 (1998). https://doi.org/10.1007/s002239900504
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DOI: https://doi.org/10.1007/s002239900504