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Endothelial Cell–Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors

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Matrix Pathobiology and Angiogenesis

Part of the book series: Biology of Extracellular Matrix ((BEM,volume 12))

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Abstract

Integrin-mediated interaction of cells with proteins present in the extracellular matrix and basement membranes direct many cellular processes required for both normal and pathological processes. These interactions guide angiogenesis and vessel homeostasis, both in the embryo and the adult. Mouse genetic studies have explored the contribution of individual integrin heterodimers; laminins and their integrin receptors have emerged as important regulators of these processes. This chapter discusses findings from both in vivo studies and organotypic cell culture models that provide insight into the molecular mechanisms by which the laminin-binding integrins α3β1, α6β1, α6β4, and their ligands, laminin-411 and laminin-511, regulate endothelial cell signaling, cell–cell interactions, and gene expression that contribute to the regulation of endothelial cell function in angiogenesis and vessel homeostasis.

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Authors and Affiliations

  1. Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, USA

    Susan E. LaFlamme

  2. Translational Research Laboratories, University of Pennsylvania, Philadelphia, PA, USA

    Hao Xu

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Correspondence to Susan E. LaFlamme .

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  1. Laboratory of Molecular Pharmacology Department of Pharmacy, University of Patras, Patras, Greece

    Evangelia Papadimitriou

  2. Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, Amarillo, TX, USA

    Constantinos M. Mikelis

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LaFlamme, S.E., Xu, H. (2023). Endothelial Cell–Matrix Interactions in Angiogenesis and Vessel Homeostasis: A Focus on Laminins and Their Integrin Receptors. In: Papadimitriou, E., Mikelis, C.M. (eds) Matrix Pathobiology and Angiogenesis. Biology of Extracellular Matrix, vol 12. Springer, Cham. https://doi.org/10.1007/978-3-031-19616-4_3

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