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Risk Factors for the Incident Decline of Physical Performance in Older Men: The Prospective Strambo Study

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Abstract

Risk factors of physical performance decline in older men remain uncertain. We assessed risk factors of incident physical performance deterioration in older men followed up prospectively. In a cohort of 821 men aged 60–87, physical performance was assessed by four tests (five chair stands, standing with closed eyes, forward and backward tandem walk) at baseline, 4 and 8 years. Various predictive biological measurements were performed at baseline. Serum creatinine/ cystatin C (Cr/CysC) ratio was used as an index of muscle mass. In multivariate models, higher age, higher fat mass index (FMI = fat mass/height2), low physical activity, prior stroke and fracture were associated with poor physical performance at baseline. Higher age, low physical activity, low calcium intake, prior non-vertebral fractures, low apparent free testosterone concentration and poor health status were associated with higher risk of loss to follow-up. Low grip strength, Parkinson’s disease and stroke were associated with higher risk of incident inability to do five chair stands. Low Cr/CysC ratio and high FMI were associated with high risk of incident inability to perform forward and backward tandem walk. Sarcopenic obesity (co-occurrence of lower tertile of Cr/CysC and upper tertile of FMI) was associated with higher risk of incident inability to perform forward (OR = 3.31, 95% CI 1.88–5.84, p < 0.001) and backward tandem walk and of incident inability to perform more than one test (OR = 5.82, 95% CI 1.29–26.27, p < 0.001). In conclusion, sarcopenic obesity and poor health are associated with higher risk of incident severe decline of physical performance.

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Funding

This study was supported by grants from the Roche pharmaceutical company, Basel, Switzerland, from Agence Nationale de la Recherche (ANR-07-PHYSIO-023, ANR-10-BLAN-1137), from Abondement ANVAR (E1482.042), and from Hospices Civils de Lyon (50564).

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Authors and Affiliations

  1. INSERM UMR1033, University of Lyon, Hôpital Edouard Herriot, Pavillon F, Place d’Arsonval, 69437, Lyon, France

    Philippe Paul Wagner, Dominique Foesser, Roland Chapurlat & Pawel Szulc

  2. Department of Rheumatology, Hospices Civils de Lyon, Hôpital Edouard Herriot, Pavillon F, Place d’Arsonval, 69437, Lyon, France

    Roland Chapurlat

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  1. Philippe Paul Wagner
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Correspondence to Pawel Szulc.

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Philippe Paul Wagner, Dominique Foesser, Roland Chapurlat and Pawel Szulc declare no conflict of interest. The funding sponsors had no role in the study.

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All procedures were approved by the Independent Ethics Committee (Comité Consultatif de Protection des Personnes dans la Recherche Biomédicale Lyon A, approval number 2005-047/A). Participant consent was obtained before study initiation.

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Wagner, P.P., Foesser, D., Chapurlat, R. et al. Risk Factors for the Incident Decline of Physical Performance in Older Men: The Prospective Strambo Study. Calcif Tissue Int 110, 428–440 (2022). https://doi.org/10.1007/s00223-021-00926-0

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