Morley JE (2017) The new geriatric giants. Clin Geriatr Med 33:xi–xii
PubMed
Google Scholar
Clynes MA, Gregson CL, Bruyère O, Cooper C, Dennison EM (2020) Osteosarcopenia: where osteoporosis and sarcopenia collide. Rheumatology (Oxford) 60:529–537
Google Scholar
Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726–1733
CAS
PubMed
Google Scholar
Saag KG, Petersen J, Brandi ML, Karaplis AC, Lorentzon M, Thomas T, Maddox J, Fan M, Meisner PD, Grauer A (2017) Romosozumab or alendronate for fracture prevention in women with osteoporosis. N Engl J Med 377:1417–1427
CAS
PubMed
Google Scholar
Khosla S, Hofbauer LC (2017) Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol 5:898–907
PubMed
PubMed Central
Google Scholar
Khosla S, Shane E (2016) A crisis in the treatment of osteoporosis. J Bone Miner Res 31:1485–1487
PubMed
Google Scholar
Jha S, Wang Z, Laucis N, Bhattacharyya T (2015) Trends in media reports, oral bisphosphonate prescriptions, and hip fractures 1996–2012: an ecological analysis. J Bone Miner Res 30:2179–2187
CAS
PubMed
Google Scholar
Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P (2018) Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet 391:230–240
CAS
PubMed
Google Scholar
Miller PD, Hattersley G, Riis BJ, Williams GC, Lau E, Russo LA, Alexandersen P, Zerbini CA, Hu MY, Harris AG, Fitzpatrick LA, Cosman F, Christiansen C (2016) Effect of abaloparatide vs placebo on new vertebral fractures in postmenopausal women with osteoporosis: a randomized clinical trial. JAMA 316:722–733
CAS
PubMed
Google Scholar
Raybould G, Babatunde O, Evans AL, Jordan JL, Paskins Z (2018) Expressed information needs of patients with osteoporosis and/or fragility fractures: a systematic review. Arch Osteoporos 13:55
PubMed
PubMed Central
Google Scholar
Ghosh TS, Rampelli S, Jeffery IB, Santoro A, Neto M, Capri M, Giampieri E, Jennings A, Candela M, Turroni S, Zoetendal EG, Hermes GDA, Elodie C, Meunier N, Brugere CM, Pujos-Guillot E, Berendsen AM, De Groot L, Feskins EJM, Kaluza J, Pietruszka B, Bielak MJ, Comte B, Maijo-Ferre M, Nicoletti C, De Vos WM, Fairweather-Tait S, Cassidy A, Brigidi P, Franceschi C, O’Toole PW (2020) Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries. Gut 69:1218–1228
CAS
PubMed
Google Scholar
O’Sullivan O, Coakley M, Lakshminarayanan B, Conde S, Claesson MJ, Cusack S, Fitzgerald AP, O’Toole PW, Stanton C, Ross RP (2013) Alterations in intestinal microbiota of elderly Irish subjects post-antibiotic therapy. J Antimicrob Chemother 68:214–221
CAS
PubMed
Google Scholar
Schirmer M, Denson L, Vlamakis H, Franzosa EA, Thomas S, Gotman NM, Rufo P, Baker SS, Sauer C, Markowitz J, Pfefferkorn M, Oliva-Hemker M, Rosh J, Otley A, Boyle B, Mack D, Baldassano R, Keljo D, LeLeiko N, Heyman M, Griffiths A, Patel AS, Noe J, Kugathasan S, Walters T, Huttenhower C, Hyams J, Xavier RJ (2018) Compositional and temporal changes in the gut microbiome of pediatric ulcerative colitis patients are linked to disease course. Cell Host Microbe 24:600-610.e604
CAS
PubMed
PubMed Central
Google Scholar
Claesson MJ, Jeffery IB, Conde S, Power SE, O’Connor EM, Cusack S, Harris HM, Coakley M, Lakshminarayanan B, O’Sullivan O, Fitzgerald GF, Deane J, O’Connor M, Harnedy N, O’Connor K, O’Mahony D, van Sinderen D, Wallace M, Brennan L, Stanton C, Marchesi JR, Fitzgerald AP, Shanahan F, Hill C, Ross RP, O’Toole PW (2012) Gut microbiota composition correlates with diet and health in the elderly. Nature 488:178–184
CAS
PubMed
Google Scholar
Hendrickx G, Boudin E, Van Hul W (2015) A look behind the scenes: the risk and pathogenesis of primary osteoporosis. Nat Rev Rheumatol 11:462–474
PubMed
Google Scholar
Ibáñez L, Rouleau M, Wakkach A, Blin-Wakkach C (2019) Gut microbiome and bone. Joint Bone Spine 86:43–47
PubMed
Google Scholar
Das M, Cronin O, Keohane DM, Cormac EM, Nugent H, Nugent M, Molloy C, O’Toole PW, Shanahan F, Molloy MG, Jeffery IB (2019) Gut microbiota alterations associated with reduced bone mineral density in older adults. Rheumatology (Oxford) 58:2295–2304
Google Scholar
Nilsson AG, Sundh D, Backhed F, Lorentzon M (2018) Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial. J Intern Med 284:307–317
CAS
PubMed
Google Scholar
Jansson P-A, Curiac D, Lazou Ahrén I, Hansson F, Martinsson Niskanen T, Sjögren K, Ohlsson C (2019) Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial. The Lancet Rheumatol 1:e154–e162
Google Scholar
Ohlsson C, Sjögren K (2015) Effects of the gut microbiota on bone mass. Trends Endocrinol Metab 26:69–74
CAS
PubMed
Google Scholar
Ohlsson C, Sjögren K (2018) Osteomicrobiology: a new cross-disciplinary research field. Calcif Tissue Int 102:426–432
CAS
PubMed
Google Scholar
Sjögren K, Engdahl C, Henning P, Lerner UH, Tremaroli V, Lagerquist MK, Bäckhed F, Ohlsson C (2012) The gut microbiota regulates bone mass in mice. J Bone Miner Res 27:1357–1367
PubMed
Google Scholar
Ohlsson C, Nigro G, Boneca IG, Bäckhed F, Sansonetti P, Sjögren K (2017) Regulation of bone mass by the gut microbiota is dependent on NOD1 and NOD2 signaling. Cell Immunol 317:55–58
CAS
PubMed
Google Scholar
Li JY, Chassaing B, Tyagi AM, Vaccaro C, Luo T, Adams J, Darby TM, Weitzmann MN, Mulle JG, Gewirtz AT, Jones RM, Pacifici R (2016) Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest 126:2049–2063
PubMed
PubMed Central
Google Scholar
Quach D, Collins F, Parameswaran N, McCabe L, Britton RA (2018) Microbiota reconstitution does not cause bone loss in germ-free mice. mSphere. https://doi.org/10.1128/mSphereDirect.00545-17
Article
PubMed
PubMed Central
Google Scholar
Li JY, Yu M, Pal S, Tyagi AM, Dar H, Adams J, Weitzmann MN, Jones RM, Pacifici R (2020) Parathyroid hormone-dependent bone formation requires butyrate production by intestinal microbiota. J Clin Invest 130:1767–1781
CAS
PubMed
PubMed Central
Google Scholar
Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF (2016) Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci USA 113:E7554-e7563
CAS
PubMed
PubMed Central
Google Scholar
Dicks LMT, Mikkelsen LS, Brandsborg E, Marcotte H (2019) Clostridium difficile, the difficult “Kloster” fuelled by antibiotics. Curr Microbiol 76:774–782
CAS
PubMed
Google Scholar
Ianiro G, Tilg H, Gasbarrini A (2016) Antibiotics as deep modulators of gut microbiota: between good and evil. Gut 65:1906–1915
CAS
PubMed
Google Scholar
Gasparrini AJ, Wang B, Sun X, Kennedy EA, Hernandez-Leyva A, Ndao IM, Tarr PI, Warner BB, Dantas G (2019) Persistent metagenomic signatures of early-life hospitalization and antibiotic treatment in the infant gut microbiota and resistome. Nat Microbiol 4:2285–2297
PubMed
PubMed Central
Google Scholar
Horton DB, Scott FI, Haynes K, Putt ME, Rose CD, Lewis JD, Strom BL (2015) Antibiotic exposure and juvenile idiopathic arthritis: a case-control study. Pediatrics 136:e333-343
PubMed
PubMed Central
Google Scholar
Blaser MJ (2016) Antibiotic use and its consequences for the normal microbiome. Science 352:544–545
CAS
PubMed
PubMed Central
Google Scholar
Sultan AA, Mallen C, Muller S, Hider S, Scott I, Helliwell T, Hall LJ (2019) Antibiotic use and the risk of rheumatoid arthritis: a population-based case-control study. BMC Med 17:154
PubMed
PubMed Central
Google Scholar
Nobel YR, Cox LM, Kirigin FF, Bokulich NA, Yamanishi S, Teitler I, Chung J, Sohn J, Barber CM, Goldfarb DS, Raju K, Abubucker S, Zhou Y, Ruiz VE, Li H, Mitreva M, Alekseyenko AV, Weinstock GM, Sodergren E, Blaser MJ (2015) Metabolic and metagenomic outcomes from early-life pulsed antibiotic treatment. Nat Commun 6:7486
PubMed
Google Scholar
Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O’Fallon WM, Castro MR, Melton LJ 3rd (1999) Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 159:1750–1756
CAS
PubMed
Google Scholar
Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF (2006) Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2. Arch Intern Med 166:241–246
CAS
PubMed
Google Scholar
Gundberg CM, Lian JB, Booth SL (2012) Vitamin K-dependent carboxylation of osteocalcin: friend or foe? Adv Nutr 3:149–157
CAS
PubMed
PubMed Central
Google Scholar
Guss JD, Taylor E, Rouse Z, Roubert S, Higgins CH, Thomas CJ, Baker SP, Vashishth D, Donnelly E, Shea MK, Booth SL, Bicalho RC, Hernandez CJ (2019) The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength. Bone 127:146–154
CAS
PubMed
PubMed Central
Google Scholar
Pytlik M, Folwarczna J, Janiec W (2004) Effects of doxycycline on mechanical properties of bones in rats with ovariectomy-induced osteopenia. Calcif Tissue Int 75:225–230
CAS
PubMed
Google Scholar
Folwarczna J, Pytlik M, Janiec W (2003) Effects of doxycycline on development of changes in histomorphometric parameters of bones induced by bilateral ovariectomy in rats. Pol J Pharmacol 55:433–441
CAS
PubMed
Google Scholar
Lawenius L, Scheffler JM, Gustafsson KL, Henning P, Nilsson KH, Collden H, Islander U, Plovier H, Cani PD, de Vos WM, Ohlsson C, Sjogren K (2020) Pasteurized Akkermansia muciniphila protects from fat mass gain but not from bone loss. Am J Physiol Endocrinol Metab 318:E480–E491
CAS
PubMed
PubMed Central
Google Scholar
O’Toole PW, Marchesi JR, Hill C (2017) Next-generation probiotics: the spectrum from probiotics to live biotherapeutics. Nat Microbiol 2:17057
CAS
PubMed
Google Scholar
Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M, Muccioli GG, Delzenne NM, de Vos WM, Cani PD (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci USA 110:9066–9071
CAS
PubMed
PubMed Central
Google Scholar
Karlsson CL, Onnerfält J, Xu J, Molin G, Ahrné S, Thorngren-Jerneck K (2012) The microbiota of the gut in preschool children with normal and excessive body weight. Obesity (Silver Spring) 20:2257–2261
Google Scholar
Clarke SF, Murphy EF, O’Sullivan O, Lucey AJ, Humphreys M, Hogan A, Hayes P, O’Reilly M, Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O’Toole PW, Molloy MG, Falvey E, Shanahan F, Cotter PD (2014) Exercise and associated dietary extremes impact on gut microbial diversity. Gut 63:1913–1920
CAS
PubMed
Google Scholar
Walter J, Armet AM, Finlay BB, Shanahan F (2020) Establishing or exaggerating causality for the gut microbiome: lessons from human microbiota-associated rodents. Cell 180:221–232
CAS
PubMed
PubMed Central
Google Scholar
Li C, Huang Q, Yang R, Dai Y, Zeng Y, Tao L, Li X, Zeng J, Wang Q (2019) Gut microbiota composition and bone mineral loss-epidemiologic evidence from individuals in Wuhan, China. Osteoporos Int 30:1003–1013
CAS
PubMed
Google Scholar
Wang J, Wang Y, Gao W, Wang B, Zhao H, Zeng Y, Ji Y, Hao D (2017) Diversity analysis of gut microbiota in osteoporosis and osteopenia patients. PeerJ 5:e3450
PubMed
PubMed Central
Google Scholar
Tong TYN, Appleby PN, Armstrong MEG, Fensom GK, Knuppel A, Papier K, Perez-Cornago A, Travis RC, Key TJ (2020) Vegetarian and vegan diets and risks of total and site-specific fractures: results from the prospective EPIC-Oxford study. BMC Med 18:353
PubMed
PubMed Central
Google Scholar
Jennings A, Mulligan AA, Khaw KT, Luben RN, Welch AA (2020) A mediterranean diet is positively associated with bone and muscle health in a non-mediterranean region in 25,450 men and women from EPIC-Norfolk. Nutrients 12:1154
CAS
PubMed Central
Google Scholar
Meslier V, Laiola M, Roager HM, De Filippis F, Roume H, Quinquis B, Giacco R, Mennella I, Ferracane R, Pons N, Pasolli E, Rivellese A, Dragsted LO, Vitaglione P, Ehrlich SD, Ercolini D (2020) Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome independently of energy intake. Gut 69:1258–1268
CAS
PubMed
Google Scholar
Britton RA, Irwin R, Quach D, Schaefer L, Zhang J, Lee T, Parameswaran N, McCabe LR (2014) Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol 229:1822–1830
CAS
PubMed
PubMed Central
Google Scholar
Li P, Sundh D, Ji B, Lappa D, Ye L, Nielsen J, Lorentzon M (2021) Metabolic alterations in older women with low bone mineral density supplemented with Lactobacillus reuteri. JBMR Plus 5:e10478
CAS
PubMed
PubMed Central
Google Scholar
Ohlsson C, Engdahl C, Fak F, Andersson A, Windahl SH, Farman HH, Moverare-Skrtic S, Islander U, Sjogren K (2014) Probiotics protect mice from ovariectomy-induced cortical bone loss. PLoS ONE 9:e92368
PubMed
PubMed Central
Google Scholar
Takimoto T, Hatanaka M, Hoshino T, Takara T, Tanaka K, Shimizu A, Morita H, Nakamura T (2018) Effect of Bacillus subtilis C-3102 on bone mineral density in healthy postmenopausal Japanese women: a randomized, placebo-controlled, double-blind clinical trial. Biosci Microbiota Food Health 37:87–96
CAS
PubMed
PubMed Central
Google Scholar
Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, Christensen LP, Jeppesen PB (2017) Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr 106:909–920
CAS
PubMed
Google Scholar
Jafarnejad S, Djafarian K, Fazeli MR, Yekaninejad MS, Rostamian A, Keshavarz SA (2017) Effects of a multispecies probiotic supplement on bone health in osteopenic postmenopausal women: a randomized, double-blind, controlled trial. J Am Coll Nutr 36:497–506
CAS
PubMed
Google Scholar
Wallace TC, Marzorati M, Spence L, Weaver CM, Williamson PS (2017) New Frontiers in fibers: innovative and emerging research on the gut microbiome and bone health. J Am Coll Nutr 36:218–222
PubMed
Google Scholar
Barbáchano A, Fernández-Barral A, Ferrer-Mayorga G, Costales-Carrera A, Larriba MJ, Muñoz A (2017) The endocrine vitamin D system in the gut. Mol Cell Endocrinol 453:79–87
PubMed
Google Scholar
Wu S, Yoon S, Zhang YG, Lu R, Xia Y, Wan J, Petrof EO, Claud EC, Chen D, Sun J (2015) Vitamin D receptor pathway is required for probiotic protection in colitis. Am J Physiol Gastrointest Liver Physiol 309:G341-349
CAS
PubMed
PubMed Central
Google Scholar
Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, Ackermann G, Vanderschueren D, Pauwels S, Knight R, Orwoll ES, Kado DM (2020) Vitamin D metabolites and the gut microbiome in older men. Nat Commun 11:5997
CAS
PubMed
PubMed Central
Google Scholar
Jones ML, Martoni CJ, Prakash S (2013) Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab 98:2944–2951
CAS
PubMed
Google Scholar
Charoenngam N, Shirvani A, Kalajian TA, Song A, Holick MF (2020) The effect of various doses of oral vitamin D(3) supplementation on gut microbiota in healthy adults: a randomized, double-blinded, dose-response study. Anticancer Res 40:551–556
CAS
PubMed
Google Scholar
(2020) National Diet and Nutrition Survey. In:Public Health England
Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Bonder MJ, Hansen TH, Frost F, Rühlemann MC, Turpin W, Moon JY, Kim HN, Lüll K, Barkan E, Shah SA, Fornage M, Szopinska-Tokov J, Wallen ZD, Borisevich D, Agreus L, Andreasson A, Bang C, Bedrani L, Bell JT, Bisgaard H, Boehnke M, Boomsma DI, Burk RD, Claringbould A, Croitoru K, Davies GE, van Duijn CM, Duijts L, Falony G, Fu J, van der Graaf A, Hansen T, Homuth G, Hughes DA, Ijzerman RG, Jackson MA, Jaddoe VWV, Joossens M, Jørgensen T, Keszthelyi D, Knight R, Laakso M, Laudes M, Launer LJ, Lieb W, Lusis AJ, Masclee AAM, Moll HA, Mujagic Z, Qibin Q, Rothschild D, Shin H, Sørensen SJ, Steves CJ, Thorsen J, Timpson NJ, Tito RY, Vieira-Silva S, Völker U, Völzke H, Võsa U, Wade KH, Walter S, Watanabe K, Weiss S, Weiss FU, Weissbrod O, Westra HJ, Willemsen G, Payami H, Jonkers D, Arias Vasquez A, de Geus EJC, Meyer KA, Stokholm J, Segal E, Org E, Wijmenga C, Kim HL, Kaplan RC, Spector TD, Uitterlinden AG, Rivadeneira F, Franke A, Lerch MM, Franke L, Sanna S, D'Amato M, Pedersen O, et al. (2021) Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat Genet 53:156–165
Emdin CA, Khera AV, Kathiresan S (2017) Mendelian randomization. Jama 318:1925–1926
PubMed
Google Scholar
Larsson SC (2021) Mendelian randomization as a tool for causal inference in human nutrition and metabolism. Curr Opin Lipidol 32:1–8
CAS
PubMed
Google Scholar
Ference BA, Holmes MV, Smith GD (2021) Using mendelian randomization to improve the design of randomized trials. Cold Spring Harb Perspect Med 41:1040980
Google Scholar
McDonald D, Hyde E, Debelius JW, Morton JT, Gonzalez A, Ackermann G, Aksenov AA, Behsaz B, Brennan C, Chen Y, DeRight Goldasich L, Dorrestein PC, Dunn RR, Fahimipour AK, Gaffney J, Gilbert JA, Gogul G, Green JL, Hugenholtz P, Humphrey G, Huttenhower C, Jackson MA, Janssen S, Jeste DV, Jiang L, Kelley ST, Knights D, Kosciolek T, Ladau J, Leach J, Marotz C, Meleshko D, Melnik AV, Metcalf JL, Mohimani H, Montassier E, Navas-Molina J, Nguyen TT, Peddada S, Pevzner P, Pollard KS, Rahnavard G, Robbins-Pianka A, Sangwan N, Shorenstein J, Smarr L, Song SJ, Spector T, Swafford AD, Thackray VG, Thompson LR, Tripathi A, Vázquez-Baeza Y, Vrbanac A, Wischmeyer P, Wolfe E, Zhu Q, Knight R (2018) American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems 3:17004
Debelius J, Song SJ, Vazquez-Baeza Y, Xu ZZ, Gonzalez A, Knight R (2016) Tiny microbes, enormous impacts: what matters in gut microbiome studies? Genome Biol 17:217
PubMed
PubMed Central
Google Scholar
Aurora R (2019) Confounding factors in the effect of gut microbiota on bone density. Rheumatology (Oxford) 58:2089–2090
Google Scholar
Allaband C, McDonald D, Vázquez-Baeza Y, Minich JJ, Tripathi A, Brenner DA, Loomba R, Smarr L, Sandborn WJ, Schnabl B, Dorrestein P, Zarrinpar A, Knight R (2019) Microbiome 101: studying, analyzing, and interpreting gut microbiome data for clinicians. Clin Gastroenterol Hepatol 17:218–230
PubMed
Google Scholar
Knight R, Vrbanac A, Taylor BC, Aksenov A, Callewaert C, Debelius J, Gonzalez A, Kosciolek T, McCall LI, McDonald D, Melnik AV, Morton JT, Navas J, Quinn RA, Sanders JG, Swafford AD, Thompson LR, Tripathi A, Xu ZZ, Zaneveld JR, Zhu Q, Caporaso JG, Dorrestein PC (2018) Best practices for analysing microbiomes. Nat Rev Microbiol 16:410–422
CAS
PubMed
Google Scholar
Wu GD, Chen J, Hoffmann C, Bittinger K, Chen YY, Keilbaugh SA, Bewtra M, Knights D, Walters WA, Knight R, Sinha R, Gilroy E, Gupta K, Baldassano R, Nessel L, Li H, Bushman FD, Lewis JD (2011) Linking long-term dietary patterns with gut microbial enterotypes. Science 334:105–108
CAS
PubMed
PubMed Central
Google Scholar