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Feasibility of Measuring Trabecular Bone Structure of the Proximal Femur Using 64-Slice Multidetector Computed Tomography in a Clinical Setting

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Abstract

We studied the feasibility of cancellous bone structure assessment of the proximal femur using multidetector computed tomography (MDCT) in an simulated in vivo experimental model. The proximal femur of 15 intact human cadavers was examined using 64-row MDCT using a thin-section protocol with an in-plane spatial resolution of 273 μm. High-resolution peripheral quantitative computed tomography (HR-pQCT) of the isolated specimens with a voxel size of 82 μm served as a standard of reference. Trabecular bone structure and optimized textural parameters were calculated in MDCT images and compared to measures obtained by HR-pQCT. Significant correlations between MDCT- and HR-pQCT-derived values for bone fraction (r = 0.87), trabecular separation (r = 0.66), and number (r = 0.53) were found. Parameters derived from textural analysis performed better in predicting trabecular separation (up to r = 0.86) and number (up to r = 0.83). Trabecular thickness could not be quantified correctly using MDCT, most likely due to its limited resolution. Individual parameters for assessement of trabecular microarchitecture can be measured using MDCT-derived imaging studies and a simulated in vivo setup. Thus, in vivo assessment of bone architecture in addition to BMD may be feasible in clinical practice.

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Authors and Affiliations

  1. Department of Radiology, Charité-Universitätsmedizin, Berlin, Germany

    Gerd Diederichs, Kentenich Marie, Patrik Rogalla & Ahi Issever

  2. Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California – San Francisco, San Francisco, CA, USA

    Gerd Diederichs, Thomas Link, Markus Huber, Andrew Burghardt, Sharmila Majumdar & Ahi Issever

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  1. Gerd Diederichs
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  2. Kentenich Marie
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  3. Markus Huber
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  4. Patrik Rogalla
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  5. Andrew Burghardt
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  6. Sharmila Majumdar
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  7. Ahi Issever
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Correspondence to Gerd Diederichs.

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Diederichs, G., Link, T., Marie, K. et al. Feasibility of Measuring Trabecular Bone Structure of the Proximal Femur Using 64-Slice Multidetector Computed Tomography in a Clinical Setting. Calcif Tissue Int 83, 332–341 (2008). https://doi.org/10.1007/s00223-008-9181-y

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  • DOI: https://doi.org/10.1007/s00223-008-9181-y

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