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Susceptibility for Postmenopausal Osteoporosis: Interaction Between Genetic, Hormonal and Lifestyle Factors

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Abstract

Although previous studies have established the importance of genetic, hormonal and lifestyle factors separately, the integral role of these factors on bone mass in postmenopausal women is still controversial. We examined the association of the collagen 1-alpha-1 gene (COLIA1) and vitamin D receptor gene (VDR) polymorphisms, s-IGF-I, s-25OHD and lifestyle factors with bone mineral density (BMD) in postmenopausal women. We determined anthropometric parameters, lifestyle factors, serum levels of IGF-I and 25OHD, the COLIA1 Sp1 (Mscl) and VDR (Bsml, Taql) polymorphisms by PCR and BMD by dual X-ray absorptiometry in 141 ambulatory postmenopausal Spanish women. There were significant linear correlations between S-25OHD and BMD and between s-IGF-I and BMD. BMD was statistically higher in active subjects. Of the three different polymorphisms, only the COLIA1 Sp1 polymorphism was significantly associated with BMD. In the logistic regression model, the COLIA1 Sp1 polymorphism, S-25OHD, s-IGF-I and physical activity variables were independently associated with osteoporosis. Our study shows that COLIA1 Sp1 polymorphism, S-25OHD and s-IGF-I serum levels and physical activity are independently associated with BMD in postmenopausal Spanish women.

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Acknowledgment

This work was supported by a grant from Fondo de Investigación Sanitaria (FIS: PI02/1089) and the Hospital Clínico Foundation.

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Authors and Affiliations

  1. Endocrinology Division, Hospital Torrecardenas, Almería, Spain

    Pedro Mezquita-Raya & Fernando Escobar-Jiménez

  2. Bone Metabolic Unit, Endocrinology Division, University Hospital San Cecilio, Granada, Spain

    Manuel Muñoz-Torres, Guillermo Alonso & Francisca Lopez-Rodriguez

  3. Biostatistics Department, School of Medicine, Granada, Spain

    Juan Dios de Luna

  4. Endocrinology Division, University Hospital Reina Sofía, Cordoba, Spain

    Jose Manuel Quesada, Gabriel Dorado & Fernando Luque-Recio

  5. Biochemistry Division, University Hospital San Cecilio, Granada, Spain

    Maria Estrella Ruiz-Requena

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  1. Pedro Mezquita-Raya
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  2. Manuel Muñoz-Torres
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  3. Guillermo Alonso
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Correspondence to Manuel Muñoz-Torres.

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Mezquita-Raya, P., Muñoz-Torres, M., Alonso, G. et al. Susceptibility for Postmenopausal Osteoporosis: Interaction Between Genetic, Hormonal and Lifestyle Factors. Calcif Tissue Int 75, 373–379 (2004). https://doi.org/10.1007/s00223-004-0187-9

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