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Vitamin D receptor and estrogen receptor gene polymorphisms in men with type 2 diabetes: Effects on Bone Metabolism

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Abstract

Purpose

There is an increased fracture risk in type 2 diabetes mellitus [DM] patients independent of bone mineral density [BMD], both in men and women. Estrogen receptor [ER]-alpha and vitamin D receptor [VDR] gene polymorphisms may predispose patients to increased osteoporosis and fracture risk. This study aims to analyze the relationship of the ER-alpha gene and VDR gene polymorphisms with indicators of bone turnover and BMD in male type 2 diabetic patients.

Methods

Type 2 diabetic men diagnosed with diabetes for at least one year and healthy controls were included in this cross-sectional study. BMD was measured by dual X ray absorptiometry. Gene polymorphisms were evaluated with polymerase chain reaction-restriction length polymorphism. Serum iPTH, calcium, beta-CrossLaps (cTx), osteocalcin, and free testosterone levels were also evaluated.

Results

Participants were 141 type 2 diabetic men [55 ± 8 years] and 100 healthy controls [53 ± 7 years]. BMD measurements were not statistically different between the groups. While iPTH [p < 0.05] and serum calcium levels [p = 0.03] were higher in men with type 2 DM; beta-CrossLaps [p = 0.0001], osteocalcin [p = 0.005], and free testosterone [p = 0.04] were lower than controls. The differences in terms of the frequencies of VDR Apa, Taq, Bsm, Fok and ER-alpha polymorphisms were not statistically significant between the groups. No relationship was observed between polymorphisms and BMD in both groups.

Conclusions

VDR and ER-alpha gene polymorphisms seem to have no effect on BMD and bone turnover in men with DM.

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Funding

No funding was received for conducting this study.

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Authors and Affiliations

  1. Section of Endocrinology and Metabolism, Marmara University Medical School, Istanbul, Turkey

    Dilek Gogas Yavuz & Özlem Üstay

  2. Vocational School of Health Related Professions, Department of Medical Laboratory, Marmara University, Istanbul, Turkey

    Meral Yüksel

  3. Section of Endocrinology and Metabolism, Fatih Sultan Mehmet Hospital, Health Sciences University, Istanbul, Turkey

    Seda Sancak

  4. Section of Endocrinology and Metabolism, Koç University Medical School, Istanbul, Turkey

    Dilek Yazıcı & Oğuzhan Deyneli

  5. Section of Endocrinology and Metabolism, Med American Medical Center, Istanbul, Turkey

    Sema Akalın

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  1. Dilek Gogas Yavuz
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  2. Meral Yüksel
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  4. Dilek Yazıcı
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Correspondence to Dilek Yazıcı.

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Yavuz, D.G., Yüksel, M., Sancak, S. et al. Vitamin D receptor and estrogen receptor gene polymorphisms in men with type 2 diabetes: Effects on Bone Metabolism. J Diabetes Metab Disord 21, 1293–1299 (2022). https://doi.org/10.1007/s40200-022-01048-6

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  • DOI: https://doi.org/10.1007/s40200-022-01048-6

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