Abstract
Non-pulsatile tinnitus is considered to be an auditory phantom percept. The extremely emotional context of disabling tinnitus often leads to a higher level of selective attention directed toward the tinnitus. As such, tinnitus is a continuously distracting auditory event. Auditory attention is associated with the activation of the intraparietal sulcus (IPS), and modulating the IPS with 10 Hz transcranial magnetic stimulation (TMS) creates the ability to ignore salient distractors. Thus, it can be expected that modulating the parietal area might interfere with the perception of tinnitus. The effect of TMS on tinnitus is evaluated using a double-cone coil tilted to the left parietal area in 24 individuals (study 1) and in 40 individuals with the double-cone coil symmetrically overlying both parietal areas (study 2). When transient tinnitus suppression is noted, the patient is asked to estimate the decrease in tinnitus in percentage using the numeric rating scale. The procedure is repeated with stimulations at sham, 1 and 10 Hz, each stimulation session consisting of 200 pulses for study 1 and for study 2 stimulations at sham, 1, 5, and 10 Hz, each stimulation session consisting of 200 pulses. For both studies, the order of the different stimulation frequencies was randomized over the participants. For study 1, patients report a significant transient reduction of the tinnitus percept for 10 Hz stimulation in comparison with, respectively, pre-treatment, sham, and 1 Hz stimulation, with a suppression effect of 11.36 %. No significant effect was obtained for 1 Hz stimulation with the coil tilted toward the left parietal area. For study, 2 patients revealed a significant suppression effect on 1, 5, and 10 Hz in comparison with pre-treatment. However, only stimulation at 5 and 10 Hz had a significant difference in comparison with sham with a suppression effect of, respectively, 8.78 and 9.50 %. Our data suggest that the parietal area is involved in tinnitus perception and that 10 Hz TMS using the double-cone coil overlying the parietal area can modulate tinnitus.
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References
Beck DM, Kastner S (2005) Stimulus context modulates competition in human extrastriate cortex. Nat Neurosci 8:1110–1116. doi:10.1038/nn1501
De Ridder D, Verstraeten E, Van der Kelen K et al (2005) Transcranial magnetic stimulation for tinnitus: influence of tinnitus duration on stimulation parameter choice and maximal tinnitus suppression. Otol Neurotol 26:616–619
De Ridder D, van der Loo E, Van der Kelen K, Menovsky T, van de Heyning P, Moller A (2007a) Do tonic and burst TMS modulate the lemniscal and extralemniscal system differentially? Int J Med Sci 4:242–246
De Ridder D, van der Loo E, Van der Kelen K, Menovsky T, van de Heyning P, Moller A (2007b) Theta, alpha and beta burst transcranial magnetic stimulation: brain modulation in tinnitus. Int J Med Sci 4:237–241
Doesburg SM, Green JJ, McDonald JJ, Ward LM (2012) Theta modulation of inter-regional gamma synchronization during auditory attention control. Brain Res 1431:77–85. doi:10.1016/j.brainres.2011.11.005
Dosenbach NU, Fair DA, Miezin FM et al (2007) Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci USA 104:11073–11078. doi:10.1073/pnas.0704320104
Dosenbach NU, Fair DA, Cohen AL, Schlaggar BL, Petersen SE (2008) A dual-networks architecture of top-down control. Trends Cogn Sci 12:99–105. doi:10.1016/j.tics.2008.01.001
Eichhammer P, Kleinjung T, Landgrebe M, Hajak G, Langguth B (2007) TMS for treatment of chronic tinnitus: neurobiological effects. Prog Brain Res 166:369–375. doi:10.1016/S0079-6123(07)66035-X
Hallam RS, McKenna L, Shurlock L (2004) Tinnitus impairs cognitive efficiency. Int J Audiol 43:218–226
Hayward G, Mehta MA, Harmer C, Spinks TJ, Grasby PM, Goodwin GM (2007) Exploring the physiological effects of double-cone coil TMS over the medial frontal cortex on the anterior cingulate cortex: an H2(15)O PET study. Eur J Neurosci 25:2224–2233. doi:10.1111/j.1460-9568.2007.05430.x
Hoffman HJ, Reed GW (2004) Epidemiology of tinnitus. In: Snow JB Jr (ed) Tinnitus, theory and management. BC Decker Inc, London, pp 16–41
Jastreboff PJ (1990) Phantom auditory perception (tinnitus): mechanisms of generation and perception. Neurosci Res 8:221–254
Kastner S, De Weerd P, Desimone R, Ungerleider LG (1998) Mechanisms of directed attention in the human extrastriate cortex as revealed by functional MRI. Science 282:108–111
Khedr EM, Rothwell JC, El-Atar A (2009) One-year follow up of patients with chronic tinnitus treated with left temporoparietal rTMS. Eur J Neurol 16:404–408. doi:10.1111/j.1468-1331.2008.02522.x
Kimbrell TA, Little JT, Dunn RT et al (1999) Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry 46:1603–1613
Kleinjung T, Eichhammer P, Langguth B et al (2005) Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngol Head Neck Surg 132:566–569. doi:10.1016/j.otohns.2004.09.134
Langguth B, Zowe M, Landgrebe M et al (2006) Transcranial magnetic stimulation for the treatment of tinnitus: a new coil positioning method and first results. Brain Topogr 18:241–247. doi:10.1007/s10548-006-0002-1
May A, Hajak G, Ganssbauer S, Steffens T, Langguth B, Kleinjung T, Eichhammer P (2007) Structural brain alterations following 5 days of intervention: dynamic aspects of neuroplasticity. Cereb Cortex 17:205–210
Mevorach C, Hodsoll J, Allen H, Shalev L, Humphreys G (2010) Ignoring the elephant in the room: a neural circuit to downregulate salience. J Neurosci 30:6072–6079. doi:10.1523/JNEUROSCI.0241-10.2010
Salmi J, Rinne T, Koistinen S, Salonen O, Alho K (2009) Brain networks of bottom-up triggered and top-down controlled shifting of auditory attention. Brain Res 1286:155–164. doi:10.1016/j.brainres.2009.06.083
Schlee W, Hartmann T, Langguth B, Weisz N (2009) Abnormal resting-state cortical coupling in chronic tinnitus. BMC Neurosci 10:11. doi:10.1186/1471-2202-10-11
Searchfield GD, Morrison-Low J, Wise K (2007) Object identification and attention training for treating tinnitus. Prog Brain Res 166:441–460. doi:10.1016/S0079-6123(07)66043-9
Serences JT, Yantis S (2006) Selective visual attention and perceptual coherence. Trends Cogn Sci 10:38–45. doi:10.1016/j.tics.2005.11.008
Sparing R, Mottaghy FM (2008) Noninvasive brain stimulation with transcranial magnetic or direct current stimulation (TMS/tDCS)-From insights into human memory to therapy of its dysfunction. Methods 44:329–337. doi:10.1016/j.ymeth.2007.02.001
Speer AM, Kimbrell TA, Wassermann EM, Repella JD, Willis MW, Herscovitch P, Post RM (2000) Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry 48:1133–1141
Stevens C, Walker G, Boyer M, Gallagher M (2007) Severe tinnitus and its effect on selective and divided attention. Int J Audiol 46:208–216. doi:10.1080/14992020601102329
Suppa A, Bologna M, Gilio F, Lorenzano C, Rothwell JC, Berardelli A (2008) Preconditioning repetitive transcranial magnetic stimulation of premotor cortex can reduce but not enhance short-term facilitation of primary motor cortex. J Neurophysiol 99:564–570. doi:10.1152/jn.00753.2007
Vanneste S, Plazier M, der Loo E, de Heyning PV, Congedo M, De Ridder D (2010a) The neural correlates of tinnitus-related distress. Neuroimage 52:470–480. doi:10.1016/j.neuroimage.2010.04.029
Vanneste S, Plazier M, Van de Heyning P, De Ridder D (2010b) Transcutaneous electrical nerve stimulation (TENS) of upper cervical nerve (C2) for the treatment of somatic tinnitus. Exp Brain Res 204:283–287. doi:10.1007/s00221-010-2304-5
Vanneste S, Plazier M, van der Loo E, Ost J, Van de Heyning P, De Ridder D (2010c) Burst transcranial magnetic stimulation: which tinnitus characteristics influence the amount of transient tinnitus suppression? Eur J Neurol. doi:10.1111/j.1468-1331.2010.02987.x
Vanneste S, Langguth B, De Ridder D (2011a) Do tDCS and TMS influence tinnitus transiently via a direct cortical and indirect somatosensory modulating effect? A combined TMS-tDCS and TENS study. Brain Stimul 4:242–252. doi:10.1016/j.brs.2010.12.001
Vanneste S, Plazier M, Van de Heyning P, De Ridder D (2011b) Repetitive transcranial magnetic stimulation frequency dependent tinnitus improvement by double cone coil prefrontal stimulation. J Neurol Neurosurg Psychiatry 82:1160–1164. doi:10.1136/jnnp.2010.213959
Vanneste S, Plazier M, Van de Heyning P, De Ridder D (2011c) Repetitive transcranial magnetic stimulation frequency dependent tinnitus improvement by double cone coil prefrontal stimulation. J Neurol Neurosurg Psychiatry. doi:10.1136/jnnp.2010.213959
Watkins S, Dalton P, Lavie N, Rees G (2007) Brain mechanisms mediating auditory attentional capture in humans. Cereb Cortex 17:1694–1700. doi:10.1093/cercor/bhl080
Zenner HP, Zalaman IM (2004) Cognitive tinnitus sensitization: behavioral and neurophysiological aspects of tinnitus centralization. Acta Otolaryngol 124:436–439
Acknowledgments
The authors thank Ana Belen Elgoyhen for the suggestion that the IPS might be involved in attentional processes in tinnitus. The authors also thank Jan Ost, Bram Van Achteren, Bjorn Devree, and Pieter van Looy for their help in preparing this manuscript.
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Vanneste, S., van der Loo, E., Plazier, M. et al. Parietal double-cone coil stimulation in tinnitus. Exp Brain Res 221, 337–343 (2012). https://doi.org/10.1007/s00221-012-3176-7
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DOI: https://doi.org/10.1007/s00221-012-3176-7