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Transcranial Magnetic Stimulation for the Treatment of Tinnitus: A New Coil Positioning Method and First Results

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Summary

Auditory phantom perceptions are associated with hyperactivity of the central auditory system. Neuronavigation guided repetitive transcranial magnetic stimulation (rTMS) of the area of increased activity was demonstrated to reduce tinnitus perception. The study aimed at developing an easy applicable standard procedure for transcranial magnetic stimulation of the primary auditory cortex and to investigate this coil positioning strategy for the treatment of chronic tinnitus in clinical practice. The left gyrus of Heschl was targeted in 25 healthy subjects using a frameless stereotactical system. Based on individual scalp coordinates of the coil, a positioning strategy with reference to the 10--20-EEG system was developed. Using this coil positioning approach we started an open treatment trial. 28 patients with chronic tinnitus received 10 sessions of rTMS (intensity 110% of motor threshold, 1 Hz, 2000 Stimuli/day). Being within a range of about 20 mm diameter, the scalp coordinates for stimulating the primary auditory cortex allowed to determine a standard procedure for coil positioning. Clinical validation of this coil positioning method resulted in a significant improvement of tinnitus complaints (p<0.001). The newly developed coil positioning strategy may have the potential to offer a more easy-to-use stimulation approach for treating chronic tinnitus as compared with highly sophisticated, imaging guided treatment methods.

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Authors and Affiliations

  1. Department of Psychiatry, Psychotherapy and Psychosomatics, University of Regensburg, Regensburg, Germany

    Berthold Langguth, Marc Zowe, Michael Landgrebe, Philipp Sand, Harald Binder, Göran Hajak & Peter Eichhammer

  2. Department of Otorhinolaryngology and Audiology, University of Regensburg, Regensburg, Germany

    Tobias Kleinjung

  3. Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA

    Peter Eichhammer

  4. Department of Psychiatry, Psychosomatics and Psychotherapy, University of Regensburg, Universitaetsstrasse 84, 93053, Regensburg, Germany

    Berthold Langguth

Authors
  1. Berthold Langguth
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  2. Marc Zowe
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  3. Michael Landgrebe
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  4. Philipp Sand
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  5. Tobias Kleinjung
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  6. Harald Binder
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  7. Göran Hajak
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  8. Peter Eichhammer
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Correspondence to Berthold Langguth.

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Langguth, B., Zowe, M., Landgrebe, M. et al. Transcranial Magnetic Stimulation for the Treatment of Tinnitus: A New Coil Positioning Method and First Results. Brain Topogr 18, 241–247 (2006). https://doi.org/10.1007/s10548-006-0002-1

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  • DOI: https://doi.org/10.1007/s10548-006-0002-1

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