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Characterization of anti-obesity compounds from soybean paste

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Abstract

Obesity is the fifth leading cause of death globally. At least 2.8 million adults die each year as a result of being overweight. Therefore, the development of an efficient lipid inhibitor for the biological effects of obesity is highly needed. The discovery of bioactive compounds from food is one possible way to control obesity and to prevent or reduce the risks of various obesity-related diseases. In this study, we found that 7,3′,4′-trihydroxyisoflavone from Korean soybean paste has remarkable anti-obesity activity in vitro and in vivo. Treatment with 7,3′,4′-trihydroxyisoflavone significantly reduced the adipose tissue weight to 1.6/100 g of body weight in high-fat mice. In addition, in 7,3′,4′-trihydroxyisoflavone-treated mice, a significant reduction in the serum triglyceride and T-cholesterol was observed at 29 and 37 %, respectively. These results support the hypothesis that 7,3′,4′-trihydroxyisoflavone is expected to create a therapeutic interest in its use for the treatment of obesity.

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Acknowledgments

This work was supported by grant from Creative Research Project of National Nuclear R&D Project, KAERI by the Ministry of Science, ICT and Future Planning (MSIP) of Korea.

Conflict of interest

The authors declare that they have no conflict of interest.

Compliance with Ethics Requirements

All institutional and national guidelines for the care and use of laboratory animals were followed.

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Authors and Affiliations

  1. Division of Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk, 580-185, South Korea

    Changhyun Roh, S. M. Nasir Uddin & Jin Kyu Kim

  2. Chonnam National University Medical School, 5, Hak-dong, Dong-Gu, Gwangju, 501-841, South Korea

    Se Jy Lee

  3. Daegu Regional Environmental Office, Government Complex, Ministry of Environment, Hwaam-ro, Dalseo-Gu, Daegu, 704-841, South Korea

    ChanKyu Kang

Authors
  1. Changhyun Roh
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  2. Se Jy Lee
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  3. S. M. Nasir Uddin
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  4. Jin Kyu Kim
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  5. ChanKyu Kang
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Corresponding authors

Correspondence to Changhyun Roh or ChanKyu Kang.

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Roh, C., Lee, S.J., Nasir Uddin, S.M. et al. Characterization of anti-obesity compounds from soybean paste. Eur Food Res Technol 240, 865–869 (2015). https://doi.org/10.1007/s00217-014-2390-x

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  • DOI: https://doi.org/10.1007/s00217-014-2390-x

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