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Antihyperglycemic, antihyperlipidemic, and antioxidant effects of Chaenomeles sinensis fruit extract in streptozotocin-induced diabetic rats

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Abstract

The rising incidence of diabetes mellitus (DM) is alarming and becoming a major health problem worldwide, which is mainly associated with hyperglycemia, abnormal lipid, and antioxidant profiles. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care, including DM. Based on these facts, in this study, the antihyperglycemic, antihyperlipidemic, and antioxidant properties of Chaenomeles sinensis fruits extract (CSFE) were investigated in streptozotocin (STZ)-induced (55 mg/kg body weight) diabetic rats. CSFE was found to be rich in total phenolics and flavonoid contents. The following assays were performed: fasting blood glucose, hemoglobin (Hb), blood urea nitrogen (BUN), serum total cholesterol (TC), serum triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), serum glutamic pyruvic transaminase/alanine aminotransferase (SGPT/ALT), serum glutamic oxaloacetic transaminase/aspartate aminotransaminase (SGOT/AST), liver glycogen content and superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) contents in liver and kidney. Oral administration of CSFE (500 mg/kg body weight) significantly decreased fasting blood glucose, BUN, and serum TC, TG, LDL-C, SGPT/ALT, and SGOT/AST, while it increased blood Hb content and HDL-C in diabetic rats. Furthermore, CSFE treatment significantly increased liver glycogen content, SOD, GSH, and CAT levels in diabetic rats. The results showed that CSFE significantly inhibited the progression of diabetes induced by STZ, and the inhibitory effect of CSFE on diabetes might be associated with its hypoglycemic effect, modulation of lipid metabolism, and its ability to scavenge free radicals.

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Acknowledgments

This research was financially supported by Seo Chun Gun and National Research Foundation of Korea.

Conflict of interest statement

The authors declare that there are no conflicts of interest.

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Authors and Affiliations

  1. Department of Biology, Kongju National University, Kongju, 314-701, Republic of Korea

    Sandesh Sancheti, Shruti Sancheti, Mayur Bafna & Sung-Yum Seo

  2. Korean Collection of Herbal Extract, Inc., Kongju, 314-701, Republic of Korea

    Sung-Yum Seo

Authors
  1. Sandesh Sancheti
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  2. Shruti Sancheti
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  3. Mayur Bafna
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  4. Sung-Yum Seo
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Corresponding author

Correspondence to Sung-Yum Seo.

Additional information

S. Sancheti and S. Sancheti contributed equally to this work.

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Sancheti, S., Sancheti, S., Bafna, M. et al. Antihyperglycemic, antihyperlipidemic, and antioxidant effects of Chaenomeles sinensis fruit extract in streptozotocin-induced diabetic rats. Eur Food Res Technol 231, 415–421 (2010). https://doi.org/10.1007/s00217-010-1291-x

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  • DOI: https://doi.org/10.1007/s00217-010-1291-x

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