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Voltammetric trace analysis of DNA and RNA

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Abstract

A voltammetric determination of DNA/RNA is described. The new aspect is the use of the extracellular endonuclease Serratia marcescens in the sample preparation. Using this enzyme it is possible to determine DNA/RNA with a detection limit of 2–5 pg/mL. This satisfies the requirements of the WHO and the FDA.

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Authors and Affiliations

  1. Technical University of Clausthal, Institute of Inorganic and Analytical Chemistry, Paul-Ernst-Str. 4, 38678 Clausthal-Zellerfeld, Germany, , , , , , DE

    S. Reher, Y. Lepka & G. Schwedt

Authors
  1. S. Reher
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  2. Y. Lepka
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  3. G. Schwedt
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Received: 16 May 2000 / Revised: 21 July 2000 / Accepted: 23 July 2000

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Reher, S., Lepka, Y. & Schwedt, G. Voltammetric trace analysis of DNA and RNA. Fresenius J Anal Chem 368, 720–726 (2000). https://doi.org/10.1007/s002160000560

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  • DOI: https://doi.org/10.1007/s002160000560

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