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Bifunctional nanozyme of copper organophyllosilicate for the ultrasensitive detection of hydroquinone

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Abstract

The rapid development of nanozymes for ultrasensitive detection of contaminate has resulted in considerable attention. Herein, a carboxyl- and aminopropyl-functionalized copper organophyllosilicate (Cu-CAP) was synthesized by a facile, one-pot sol–gel method. The bifunctional groups endow it with superior catalytic activity than that of natural enzyme. Besides, it possesses outstanding catalytic stability under harsh conditions such as high temperature, extremely high or low pH, and high salinity. Apart from laccase-mimetic activity, Cu-CAP also shows oxidation of the peroxidase substrate 3,3′,5,5′-tetramethylbenzidine (TMB) to the blue-colored TMBox in the presence of H2O2, which is similar to natural horseradish peroxidase (HRP). Interestingly, this colorimetric system was suppressed by hydroquinone (HQ) specifically. Inspired by this, Cu-CAP was used to develop a highly sensitive and selective colorimetric method for the determination of HQ. This assay displayed an extremely low detection limit of 23 nM and was applied for the detection of HQ in environmental water with high accuracy. This approach offers a new route for the rational design of high performance nanozymes for environmental and biosensing applications.

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Funding

This work was supported by the National Natural Science Foundation of China (NSFC, grant numbers 42061134018, 42011530085, and 41877323), the Russian Science Foundation (RSF, grant number 21–47-00019), the Sichuan Science and Technology Program (grant number 2019JDJQ0056), and the Postgraduate Innovation Fund Project by Southwest University of Science and Technology (grant number 20YCX0022).

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Authors and Affiliations

  1. School of Environment and Resource, Key Laboratory of Solid Waste Treatment and Resource Recycle of Ministry of Education, Southwest University of Science and Technology, Mianyang, 621010, Sichuan, China

    Rui Lv, Shiyong Sun, Jin Liu, Ke Wang, Faqin Dong, Xiaoqin Nie & Daoyong Tan

  2. School of Chemistry and Chemical Engineering, Mianyang Teachers’ College, Mianyang, 621000, Sichuan, China

    Rui Lv

  3. Yushkin’s Institute of Geology, Komi Science Center, Ural Branch of RAS, ul. Pervomayskaya, 54, Syktyvkar, 167982, Russia

    Yevgeny A. Golubev & Olga B. Kotova

  4. Saint-Petersburg Mining University, 21st Line, St. Petersburg, 199106, Russia

    Elena L. Kotova

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  1. Rui Lv
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Lv, R., Sun, S., Liu, J. et al. Bifunctional nanozyme of copper organophyllosilicate for the ultrasensitive detection of hydroquinone. Anal Bioanal Chem 414, 1039–1048 (2022). https://doi.org/10.1007/s00216-021-03728-3

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  • DOI: https://doi.org/10.1007/s00216-021-03728-3

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