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Ultra-sensitive film sensor based on Al2O3–Au nanoparticles supported on PDDA-functionalized graphene for the determination of acetaminophen

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Abstract

An electrochemical sensor of acetaminophen based on poly(diallyldimethylammonium chloride) (PDDA)-functionalized reduced graphene-loaded Al2O3–Au nanoparticles coated onto glassy carbon electrode (Al2O3–Au/PDDA/reduced graphene oxide (rGO)/glass carbon electrode (GCE)) were prepared by layer self-assembly technique. The as-prepared electrode-modified materials were characterized by scanning electron microscopy, X-ray powder diffraction, and Fourier transform infrared spectroscopy. The electrocatalytic performances of Al2O3–Au/PDDA/rGO-modified glassy carbon electrode toward the acetaminophen were investigated by cyclic voltammetry and differential pulse voltammetry. The modified electrodes of graphene oxide (GO)/GCE, PDDA/rGO/GCE, and Al2O3–Au/PDDA/rGO/GCE were constructed for comparison and learning the catalytic mechanism. The research showed Al2O3–Au/PDDA/rGO/GCE having good electrochemical performance, attributing to the synergetic effect that comes from the special nanocomposite structure and physicochemical properties of Al2O3–Au nanoparticles and graphene. A low detection limit of 6 nM (S/N = 3) and a wide linear detection range from 0.02 to 200 μM (R 2 = 0.9970) was obtained. The preparation of sensor was successfully applied for the detection of acetaminophen in commercial pharmaceutical pills.

Schematic diagram of synthesis of Al2O3–Au/PDDA/rGO/GCE

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (NSFC; nos. 21345005 and 21205048), the Shandong Provincial Natural Science Foundation of China (no. ZR2012BM020), and the Scientific and Technological Development Plan Item of Jinan City in China (no. 201202088).

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Authors and Affiliations

  1. Key Laboratory of Chemical Sensing and Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Shandong, 250022, China

    Jianbo Li, Weiyan Sun, Xiaojiao Wang, Huimin Duan, Yanhui Wang, Yuanling Sun, Chaofan Ding & Chuannan Luo

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  1. Jianbo Li
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  2. Weiyan Sun
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  3. Xiaojiao Wang
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Correspondence to Chuannan Luo.

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Li, J., Sun, W., Wang, X. et al. Ultra-sensitive film sensor based on Al2O3–Au nanoparticles supported on PDDA-functionalized graphene for the determination of acetaminophen. Anal Bioanal Chem 408, 5567–5576 (2016). https://doi.org/10.1007/s00216-016-9654-1

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  • DOI: https://doi.org/10.1007/s00216-016-9654-1

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