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Optical coherence tomography in biomedical research

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Abstract

Optical coherence tomography (OCT) is a noninvasive, high-resolution, interferometric imaging modality using near-infrared light to acquire cross-sections and three-dimensional images of the subsurface microstructure of biological specimens. Because of rapid improvement of the acquisition speed and axial resolution of OCT over recent years, OCT is becoming increasingly attractive for applications in biomedical research. Therefore, OCT is no longer used solely for structural investigations of biological samples but also for functional examination, making it potentially useful in bioanalytical science. The combination of in vivo structural and functional findings makes it possible to obtain thorough knowledge on basic physiological and pathological processes. Advanced applications, for example, optical biopsy in visceral cavities, have been enabled by combining OCT with established imaging modalities. This report gives an outline of the state of the art and novel trends of innovative OCT approaches in biomedical research in which the main focus is on applications in fundamental research and pre-clinical utilization.

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Acknowledgements

This research was supported by the following institutions and funds: SAB (Sächsische Aufbaubank, project 11261/1759), funding from the European Union (ESF) and the Free State of Saxony (project 080937940), the BMBF (Bundesministerium für Bildung und Forschung, NBL 3 and project 03NUK010l), the MeDDrive program of the Faculty of Medicine Carl Gustav Carus of Dresden University of Technology and the German Research Foundation (DFG) “Protective Artificial Respiration” (PAR) - KO 1814/6-1, KO 1814/6-2 and KU 1218/4-1.

Furthermore, the authors would like to thank Dr Gregor Müller from the Vascular Endothelium and Microcirculation group of Professor Morawietz (Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Germany), the group of Dr Marius Ader (Aline Höfer, Dierk Wittig; Center for Regenerative Therapies, Dresden, and Institute of Anatomy, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Germany), and, finally, the group of Professor W.M. Kübler (Institute of Physiology, Charité Berlin, Germany and St. Michael’s Hospital, Toronto, Canada) for all their support and for providing biological samples.

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  1. Dresden University of Technology, Faculty of Medicine Carl Gustav Carus, Clinical Sensoring and Monitoring, Fetscherstrasse 74, 01307, Dresden, Germany

    Julia Walther, Maria Gaertner, Peter Cimalla, Anke Burkhardt, Lars Kirsten, Sven Meissner & Edmund Koch

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  1. Julia Walther
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Correspondence to Edmund Koch.

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Julia Walther and Maria Gaertner contributed equally to this review

Published in the special issue Biophotonics with Guest Editors Jürgen Popp and Reiner Salzer.

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Walther, J., Gaertner, M., Cimalla, P. et al. Optical coherence tomography in biomedical research. Anal Bioanal Chem 400, 2721–2743 (2011). https://doi.org/10.1007/s00216-011-5052-x

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