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Use of proficiency testing materials for the calculation of detection and quantification limits in the analysis of organochlorine compounds in human serum

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Abstract

A method for the calculation of the limits of detection (LD) and quantification (LQ) for the analysis of organochlorine compounds in serum is described. The method is based on the analysis of proficiency testing materials, an external quality assessment for selected pollutants, and the study of the signal/noise ratio of chromatograms obtained from GC-ECD injection. This method provides representative results for matrix effects, instrumental variability and extraction recoveries in the analysis of serum samples.

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Acknowledgments

This research was supported by the research network INMA (G03/176) and the GRACCIE Consolider Ingenio Network (CSD2007-00067). MG thanks a grant from the Spanish Council for Scientific Research (CSIC) in the JAE-Predoctoral Program. We thank P. Alabart for her kind support with GC-ECD analyses.

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  1. Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDÆA-CSIC), Jordi Girona, 18, 08034, Barcelona, Catalonia, Spain

    Mercè Garí & Joan O. Grimalt

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  1. Mercè Garí
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  2. Joan O. Grimalt
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Correspondence to Joan O. Grimalt.

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Garí, M., Grimalt, J.O. Use of proficiency testing materials for the calculation of detection and quantification limits in the analysis of organochlorine compounds in human serum. Anal Bioanal Chem 397, 1383–1387 (2010). https://doi.org/10.1007/s00216-010-3638-3

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  • DOI: https://doi.org/10.1007/s00216-010-3638-3

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