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In vitro and intracellular sensing by using the photoluminescence of quantum dots

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Abstract

Quantum dots (QDs) have attracted increasing attention due to their unique physical and chemical properties. This article introduces recent advances in using QDs’ photoluminescence (PL) for in vitro and intracellular sensing analytes, in particular ions, and biomolecules from the last 3 years. Different sensing strategies are demonstrated and compared for increasing the detecting/sensing selectivity. The perspectives for in vitro and intracellular sensing based on QDs’ PL are also discussed.

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References

  1. Ekimov AI, Onushchenko AA (1982) Sov Phys Semicond 16:775–778

    Google Scholar 

  2. Efros AL, Efros AL (1982) Sov Phys Semicond 16:772–775

    Google Scholar 

  3. Brus LE (1983) J Chem Phys 79:5566–5571

    Article  CAS  Google Scholar 

  4. Parak WJ, Manna L, Simmel FC, Gerion D, Alivisatos P (2004) In: Schmid G (ed) Nanoparticles-from theory to application. Wiley-VCH, Weinheim, pp 4–49

    Google Scholar 

  5. Chan WC, Nie S (1998) Science 281:2016–2018

    Article  CAS  Google Scholar 

  6. Wu MX, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP (2003) Nat Biotechnol 21:41–46

    Article  CAS  Google Scholar 

  7. Rogach AL, Katsikas L, Kornowski A, Su D, Eychmüller A, Weller H (1997) Ber Bunsen Phys Chem 101:1668–1670

    CAS  Google Scholar 

  8. Murray CB, Norris DJ, Bawendi MG (1993) J Am Chem Soc 115:8706–8715

    Article  CAS  Google Scholar 

  9. Pinaud F, King D, Moore H-P, Weiss S (2004) J Am Chem Soc 126:6115–6123

    Article  CAS  Google Scholar 

  10. Pellegrino T, Manna L, Kudera S, Liedl T, Koktysh D, Rogach AL, Keller S, Rädler J, Natile G, Parak WJ (2004) Nano Lett 4:703–707

    Article  CAS  Google Scholar 

  11. Lin C-AJ, Sperling RA, Li JK, Yang T-Y, Li P-Y, Zanella M, Chang WH, Parak WJ (2008) Small 4:334–341

    Article  CAS  Google Scholar 

  12. Dabbousi BO, Rodriguez-Viejo J, Mikulec FV, Heine JR, Mattoussi H, Ober R, Jensen KF, Bawendi MG (1997) J Phys Chem B 101:9463–9475

    Article  CAS  Google Scholar 

  13. Soper SA, Brown K, Ellington A, Frazier B, Garcia-Manero G, Gau V, Gutman SI, Hayes DF, Korte B, Landers JL et al (2006) Biosens Bioelectron 21:1932–1942

    Article  CAS  Google Scholar 

  14. Clark HA, Barker SLR, Brasuel M, Miller MT, Monson E, Parus S, Shi ZY, Song A, Thorsrud B, Kopelman R et al (1998) Sens Actuators B Chem 51:12–16

    Article  Google Scholar 

  15. Stoll C, Kudera S, Parak WJ, Lisdat F (2006) Small 2:741–743

    Article  CAS  Google Scholar 

  16. Yildiz HB, Tel-Vered R, Willner I (2008) Angew Chem Int Ed 47:6629–6633

    Article  CAS  Google Scholar 

  17. Stoll C, Gehring C, Schubert K, Zanella M, Parak WJ, Lisdata F (2008) Biosens Bioelectron 24:260–265

    Article  CAS  Google Scholar 

  18. Privett BJ, Shin JH, Schoenfisch MH (2008) Anal Chem 80:4499–4517

    Article  CAS  Google Scholar 

  19. Medintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005) Nat Mater 4:435–446

    Article  CAS  Google Scholar 

  20. Costa-Fernández JM, Pereiro R, Sanz-Medel A (2006) Trends Anal Chem 25:207–218

    Article  CAS  Google Scholar 

  21. Sapsford KE, Pons T, Medintz IL, Mattoussi H (2006) Sensors 6:925–953

    Article  CAS  Google Scholar 

  22. Lin C-AJ, Liedl T, Sperling RA, Fernández-Argüelles MT, Costa-Fernández JM, Pereiro R, Sanz-Medel A, Chang WH, Parak WJ (2007) J Mater Chem 17:1343–1346

    Article  CAS  Google Scholar 

  23. Somers RC, Bawendi MG, Nocera DG (2007) Chem Soc Rev 36:579–591

    Article  CAS  Google Scholar 

  24. Raymo FM, Yildiz I (2007) Phys Chem Chem Phys 9:2036–2043

    Article  CAS  Google Scholar 

  25. Gill R, Zayats M, Willner I (2008) Angew Chem Int Ed 47:7602–7625

    Article  CAS  Google Scholar 

  26. Moore DE, Patel K (2001) Langmuir 17:2541–2544

    Article  CAS  Google Scholar 

  27. Chen YR, Rosenzweig Z (2002) Anal Chem 74:5132–5138

    Article  CAS  Google Scholar 

  28. Fernandez-Argüelles MT, Jin WJ, Costa-Fernandez JM, Pereiro R, Sanz-Medel A (2005) Anal Chim Acta 549:20–25

    Article  CAS  Google Scholar 

  29. Susha AS, Munoz_Javier A, Parak WJ, Rogach AL (2006) Colloids Surf A Physicochem Eng Asp 281:40–43

    Article  CAS  Google Scholar 

  30. Lai S, Chang X, Mao J, Zhai Y, Lian N, Zheng H (2007) Ann Chim 97:109–121

    Article  CAS  Google Scholar 

  31. Wang JH, Wang HQ, Zhang HL, Li XQ, Hua XF, Cao YC, Huang ZL, Zhao YD (2007) Anal Bioanal Chem 388:969–974

    Article  CAS  Google Scholar 

  32. Liu FC, Chen YM, Lin JH, Tseng WL (2009) J Colloid Interface Sci 337:414–419

    Google Scholar 

  33. Xia Y, Zhu C (2008) Analyst 133:928–932

    Article  CAS  Google Scholar 

  34. Tang B, Niu J, Yu C, Zhuo L, Ge J (2005) Chem Commun (Camb) 4184–4186

  35. Ali EM, Zheng Y, Yu HH, Ying JY (2007) Anal Chem 79:9452–9458

    Article  CAS  Google Scholar 

  36. Banerjee S, Kar S, Santra S (2008) Chem Commun (Camb) 3037–3039

  37. Wang X, Guo X (2009) Analyst 134:1348–1354

    Article  CAS  Google Scholar 

  38. Fernández-Argüelles MT, Yakovlev A, Sperling RA, Luccardini C, Gaillard S, Medel AS, Mallet J-M, Brochon J-C, Feltz A, Oheim M et al (2007) Nano Lett 7:2613–2617

    Article  CAS  Google Scholar 

  39. Medintz IL, Clapp AR, Mattoussi H, Goldman ER, Fisher B, Mauro JM (2003) Nat Mater 2:630–638

    Article  CAS  Google Scholar 

  40. Patolsky F, Gill R, Weizmann Y, Mokari T, Banin U, Willner I (2003) J Am Chem Soc 125:13918–13919

    Article  CAS  Google Scholar 

  41. Snee PT, Somers RC, Nair G, Zimmer JP, Bawendi MG, Nocera DG (2006) J Am Chem Soc 128:13320–13321

    Article  CAS  Google Scholar 

  42. Ruedas-Rama MJ, Wang X, Hall EA (2007) Chem Commun (Camb) 1544–1546

  43. Callan JF, Mulrooney RC, Kamila S, McCaughan B (2008) J Fluoresc 18:527–532

    Article  CAS  Google Scholar 

  44. Mulrooney RC, Singh N, Kaur N, Callan JF (2009) Chem Commun (Camb) 686–688

  45. Ruedas-Rama MJ, Hall EA (2008) Analyst 133:1556–1566

    Article  CAS  Google Scholar 

  46. Shang L, Zhang L, Dong S (2009) Analyst 134:107–113

    Article  CAS  Google Scholar 

  47. Touceda-Varela A, Stevenson EI, Galve-Gasion JA, Dryden DT, Mareque-Rivas JC (2008) Chem Commun (Camb) 1998–2000

  48. Yan XQ, Shang ZB, Zhang Z, Wang Y, Jin WJ (2009) Luminescence 24:255–259

    Google Scholar 

  49. Huang CP, Li YK, Chen TM (2007) Biosens Bioelectron 22:1835–1838

    Article  CAS  Google Scholar 

  50. Vinayaka AC, Basheer S, Thakur MS (2009) Biosens Bioelectron 24:1615–1620

    Article  CAS  Google Scholar 

  51. Wang Y, Tang ZY, Correa-Duarte MA, Pastoriza-Santos I, Giersig M, Kotov NA, Liz-Marzan LM (2004) J Phys Chem B 108:15461–15469

    Article  CAS  Google Scholar 

  52. Zhang Y, Li Y, Yan XP (2009) Anal Chem 81:5001–5007

    Article  CAS  Google Scholar 

  53. Wu CS, Cupps JM, Fan X (2009) Nanotechnology 20:305502

    Article  CAS  Google Scholar 

  54. Lee J, Choi Y, Kim J, Park E, Song R (2009) Chemphyschem 10:806–811

    Article  CAS  Google Scholar 

  55. Zhou D, Ying L, Hong X, Hall EA, Abell C, Klenerman D (2008) Langmuir 24:1659–1664

    Article  CAS  Google Scholar 

  56. Cui D, Pan B, Zhang H, Gao F, Wu R, Wang J, He R, Asahi T (2008) Anal Chem 80:7996–8001

    Article  CAS  Google Scholar 

  57. Kim GI, Kim KW, Oh MK, Sung YM (2009) Nanotechnology 20:175503

    Article  CAS  Google Scholar 

  58. Boeneman K, Mei BC, Dennis AM, Bao G, Deschamps JR, Mattoussi H, Medintz IL (2009) J Am Chem Soc 131:3828–3829

    Article  CAS  Google Scholar 

  59. Xia Z, Xing Y, So MK, Koh AL, Sinclair R, Rao J (2008) Anal Chem 80:8649–8655

    Article  CAS  Google Scholar 

  60. Yao H, Zhang Y, Xiao F, Xia Z, Rao J (2007) Angew Chem Int Ed Engl 46:4346–4349

    Article  CAS  Google Scholar 

  61. Medintz IL, Mattoussi H (2009) Phys Chem Chem Phys 11:17–45

    Article  CAS  Google Scholar 

  62. Chen Z, Li G, Zhang L, Jiang J, Li Z, Peng Z, Deng L (2008) Anal Bioanal Chem 392:1185–1188

    Article  CAS  Google Scholar 

  63. Callan JF, Mulrooney RC, Kamila S (2008) J Fluoresc 18:1157–1161

    Article  CAS  Google Scholar 

  64. Freeman R, Bahshi L, Finder T, Gill R, Willner I (2009) Chem Commun 764–766

  65. Freeman R, Finder T, Bahshi L, Willner I (2009) Nano Lett 9:2073–2076

    Article  CAS  Google Scholar 

  66. Gill R, Bahshi L, Freeman R, Willner I (2008) Angew Chem Int Ed 47:1676–1679

    Article  CAS  Google Scholar 

  67. Bahshi L, Freeman R, Gill R, Willner I (2009) Small 5:676–680

    Article  CAS  Google Scholar 

  68. Han B, Yuan J, Wang E (2009) Anal Chem 81:5569–5573

    Article  CAS  Google Scholar 

  69. Freeman R, Gill R, Shweky I, Kotler M, Banin U, Willner I (2009) Angew Chem Int Ed 48:309–313

    Article  CAS  Google Scholar 

  70. Orndorff RL, Rosenthal SJ (2009) Nano Lett 9:2589–2599

    Article  CAS  Google Scholar 

  71. Sun YH, Liu YS, Vernier PT, Liang CH, Chong SY, Marcu L, Gundersen MA (2006) Nanotechnology 4469

  72. Parak WJ, Boudreau R, Gros ML, Gerion D, Zanchet D, Micheel CM, Williams SC, Alivisatos AP, Larabell CA (2002) Adv Mater 14:882–885

    Article  CAS  Google Scholar 

  73. Delehanty JB, Mattoussi H, Medintz IL (2009) Anal Bioanal Chem 393:1091–1105

    Article  CAS  Google Scholar 

  74. Luccardini C, Yakovlev A, Gaillard S, Hoff Mvt, Alberola AP, Mallet J-M, Parak WJ, Feltz A, Oheim M (2007) J Biomed Biotechnol 2007: Article ID 68963

  75. Röcker C, Pötzl M, Zhang F, Parak WJ, Nienhaus GU (2009) Nat Nanotechnol 4:577–580

    Article  CAS  Google Scholar 

  76. Peteiro-Cattelle J, Rodriguez-Pedreira M, Zhang F, Rivera Gil P, del Mercato LL, Parak WJ (2009) Nanomedicine 4:967–979

    Article  Google Scholar 

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Acknowledgements

This work was supported by the European Union (grant NANOGNOSTICS).

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Correspondence to Feng Zhang.

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Zhang, F., Ali, Z., Amin, F. et al. In vitro and intracellular sensing by using the photoluminescence of quantum dots. Anal Bioanal Chem 397, 935–942 (2010). https://doi.org/10.1007/s00216-010-3609-8

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  • DOI: https://doi.org/10.1007/s00216-010-3609-8

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