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Microwave-assisted sol–gel synthesis for molecular imprinting

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Abstract

Molecularly imprinted polymers have been the subject of intense research for several decades in both academic and industrial settings. In this paper, we introduce a novel microwave-assisted sol–gel method for molecular imprinting of silica microspheres. The microspheres were characterized, and their adsorption of imprint and non-imprint molecules was investigated. The dye molecules methyl orange and ethyl orange were used as templates. Good molecular imprinting was observed as evaluated by the re-adsorption of dye into the silica matrix followed by the removal of dye from the supernatant solution.

We describe a novel microwave-assisted sol-gel method for molecular imprinting of silica microspheres. The microspheres were smooth and well dispersed. The adsorption capacity, relative adsorption capacity, specific adsorption capacity, and different effects for imprinted and non-imprinted microspheres were determined for dye molecules as the molecular imprints. This synthetic methodology has promise for use in preparation of molecularly imprinted solids

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Acknowledgments

We thank Professor Kenneth S. Suslick for editorial assistance in the final draft of this paper. We gratefully acknowledge the financial support provided by the Center for Advanced Study, the Department of Chemistry, and the University of Illinois. We also thank the center for microanalysis of materials in the Frederick Seitz Materials Research Laboratory at UIUC, which is partially supported by the U.S. Department of Energy under grants DE-FG02-07ER46453 and DE-FG02-07ER46471. Supporting information is available online from Wiley InterScience or from the authors.

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Authors and Affiliations

  1. Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Ave., Urbana, IL, 61801, USA

    Liang Feng, Barathi Pamidighantam & Paul C. Lauterbur

  2. Dalian Institute of Chemical Physics, Department of Instrumentation and Analytical Chemistry, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian, 116023, China

    Liang Feng

Authors
  1. Liang Feng
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  2. Barathi Pamidighantam
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  3. Paul C. Lauterbur
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Corresponding author

Correspondence to Liang Feng.

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Prof. Lauterbur passed away shortly before the completion of this work.

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Feng, L., Pamidighantam, B. & Lauterbur, P.C. Microwave-assisted sol–gel synthesis for molecular imprinting. Anal Bioanal Chem 396, 1607–1612 (2010). https://doi.org/10.1007/s00216-009-3311-x

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  • DOI: https://doi.org/10.1007/s00216-009-3311-x

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