Abstract
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal side-effect of antipsychotic drug therapy, especially of dopamine receptor antagonists. As a dose relationship has been postulated, low dose neuroleptization would be expected to help to avoid this side-effect. In contrast, we report on a 21-year-old female following low dose fluphenazine treatment with 2.5 mg/day. The patient recovered from NMS after 3 days of dantrolene administration. Eventually, remission from psychotic symptoms was achieved with clozapine. At 8-month follow-up, psychopathology remained stable and there were no more signs of NMS.
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Received: 8 July 1998 / Final version: 6 November 1998
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Gönner, F., Baumgartner, R., Schüpbach, D. et al. Neuroleptic malignant syndrome during low dosed neuroleptic medication in first-episode psychosis: a case report. Psychopharmacology 144, 416–418 (1999). https://doi.org/10.1007/s002130051026
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DOI: https://doi.org/10.1007/s002130051026