Abstract
Rationale
Cocaine use not only depends on the reinforcing properties of the drug, but also on its pharmacological effects on alternative nondrug activities. In animal models investigating choice between cocaine and alternative sweet rewards, the latter influence can have a dramatic impact on choice outcomes. When choosing under cocaine influence is prevented by imposing sufficiently long intervals between choice trials, animals typically prefer the sweet reward. However, when choosing under the drug influence is permitted, animals shift their preference in favor of cocaine.
Objectives
We previously hypothesized that this preference shift is mainly due to a direct suppression of responding for sweet reward by cocaine pharmacological effects. Here we tested this hypothesis by making rats tolerant to this drug-induced behavioral suppression.
Results
Contrary to our expectation, tolerance did not prevent rats from shifting their preference to cocaine when choosing under the influence.
Conclusion
Thus, other mechanisms must be invoked to explain the influence of cocaine intoxication on choice outcomes.
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Funding
This work was supported by the French Research Council (CNRS), the Université de Bordeaux, the French National Agency (ANR-2010-BLAN-1404–01), the Ministère de l’Enseignement Supérieur et de la Recherche (MESR), the Fondation pour la Recherche Médicale (FRM DPA20140629788), and the Peter und Traudl Engelhorn foundation.
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Conceptualization, SHA and YV; methodology, SHA and YV; investigation, YV; formal analysis, YV; supervision, SHA; visualization, YV; writing (original draft), YV; writing (review and editing), SHA and YV.
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This manuscript has been posted as a preprint on bioRχiv: https://www.biorxiv.org/content/10.1101/2021.04.02.438165v1 (Vandaele and Ahmed 2021).
This article belongs to a Special Issue on Nature vs. Nurture in Addiction Research
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Vandaele, Y., Ahmed, S.H. Choosing between cocaine and sucrose under the influence: testing the effect of cocaine tolerance. Psychopharmacology 239, 1053–1063 (2022). https://doi.org/10.1007/s00213-021-05987-5
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DOI: https://doi.org/10.1007/s00213-021-05987-5