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Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system

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Abstract

Aim

The present investigation explored the modulatory role of serotonergic transmission in the acute ethanol-induced effects on immobility time in the mouse forced swim test (FST).

Methods and results

Acute i.p. administration of ethanol (20% w/v, 2 or 2.5 g/kg, i.p.) decreased the immobility time in FST of mice, indicating its antidepressant-like effect while lower doses of ethanol (1, 1.5 g/kg, i.p.) were devoid of any effect in the FST. The mice pre-treated with a sub-effective dose of 5-HT2A agonist, DOI (10 μg/mouse, i.c.v.) or 5-HT1A receptor antagonist, WAY 100635 (0.1 μg/mouse, i.c.v.) but not with the 5-HT2A/2C antagonist, ketanserin (1.5 μg/mouse, i.c.v.) exhibited a synergistic reduction in the immobility time induced by sub-effective dose of ethanol (1.5 g/kg, i.p.). On the other hand, ethanol (2.5 g/kg, i.p.) failed to decrease the immobility time in mice, pre-treated with 5-HT1A agonist, 8-OH-DPAT (0.1 μg/mouse, i.c.v.) or ketanserin (1.5 μg/mouse, i.c.v.). In addition, pre-treatment with a 5-HT neuronal synthesis inhibitor, p-CPA (300 mg/kg, i.p. × 3 days) attenuated the anti-immobility effect ethanol (2.5 g/kg, i.p.) in mouse FST.

Conclusions

Thus, the results of the present study points towards the essentiality of the central 5-HT transmission at the synapse for the ethanol-induced antidepressant-like effect in the FST wherein the regulatory role of the 5-HT1A receptor or contributory role of the 5-HT2A/2C receptor-mediated mechanism is proposed in the anti-immobility effect of acute ethanol in mouse FST.

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Acknowledgements

Authors extend thanks to our Hon’ble Chairman, Lokmanya Tilak Jankalyan Sanstha, Nagpur (M.H.) and Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Bilaspur, (C.G.), India, for providing the necessary facilities and funding for this research project.

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  1. Department of Pharmacology, Institute of Pharmaceutical Sciences, Guru Ghasidas University (A Central University), Koni, Bilaspur, 495009, Chhattisgarh, India

    Nishant S. Jain & Lokesh Verma

  2. Department of Pharmacology, J. L. Chaturvedi College of Pharmacy, Higna Road, MIDC, Nagpur, Maharashtra, India

    Uday Kannamwar

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  1. Nishant S. Jain
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Jain, N.S., Kannamwar, U. & Verma, L. Ethanol induced antidepressant-like effect in the mouse forced swimming test: modulation by serotonergic system. Psychopharmacology 234, 447–459 (2017). https://doi.org/10.1007/s00213-016-4478-4

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